Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican
Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican
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DOI：
10.1016/j.neuron.2017.06.028
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发表时间：
2017-08-02
期刊：
影响因子：
16.2
通讯作者：
Rico, Beatriz
中科院分区：
文献类型：
--
作者：
Favuzzi, Emilia;Marques-Smith, Andre;Rico, Beatriz
活动依赖性神经元可塑性是神经系统适应感觉经验的基本机制。一些证据表明，小白蛋白（PV+）的中间神经元是必不可少的，在这个过程中，但潜在的分子机制的影响，经验对中间神经元的可塑性仍然知之甚少。包裹PV+细胞的神经元周网（PNN）是长期以来发挥这种作用的候选者，但它们的精确贡献仍然难以捉摸。我们表明，PNN蛋白短蛋白聚糖是一个重要的调节器的中间神经元可塑性。我们发现，短蛋白聚糖同时控制PV+细胞的可塑性的细胞和突触形式，通过调节钾通道和AMPA受体的本地化，分别。通过调节Brevican水平，经验在PV+细胞中引入了学习和记忆所需的精确分子和细胞修饰。这些发现揭示了一个分子程序，通过该程序，PNN蛋白通过动态门控PV+中间神经元功能促进对经验的适当行为反应。
Activity-dependent neuronal plasticity is a fundamental mechanism through which the nervous system adapts to sensory experience. Several lines of evidence suggest that parvalbumin (PV+) interneurons are essential in this process, but the molecular mechanisms underlying the influence of experience on interneuron plasticity remain poorly understood. Perineuronal nets (PNNs) enwrapping PV+ cells are long-standing candidates for playing such a role, yet their precise contribution has remained elusive. We show that the PNN protein Brevican is a critical regulator of interneuron plasticity. We find that Brevican simultaneously controls cellular and synaptic forms of plasticity in PV+ cells by regulating the localization of potassium channels and AMPA receptors, respectively. By modulating Brevican levels, experience introduces precise molecular and cellular modifications in PV+ cells that are required for learning and memory. These findings uncover a molecular program through which a PNN protein facilitates appropriate behavioral responses to experience by dynamically gating PV+ interneuron function.