Effect of the protein kinase inhibitors, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine H-7 and N-(2-[methylamino]ethyl)-5-isoquinoline-sulfonamide H-8 on Lewis lung carcinoma tumor progression.
Effect of the protein kinase inhibitors, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine H-7 and N-(2-[methylamino]ethyl)-5-isoquinoline-sulfonamide H-8 on Lewis lung carcinoma tumor progression.
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蛋白激酶抑制剂 1-(5-异喹啉磺酰基)-2-甲基哌嗪 H-7 和 N-(2-[甲基氨基]乙基)-5-异喹啉磺酰胺 H-8 对 Lewis 肺癌肿瘤进展的影响。
DOI：
10.1016/s0014-2999(98)00434-8
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发表时间：
1998
影响因子：
5
通讯作者：
S. Aliño
中科院分区：
文献类型：
--
作者：
C. Blaya;J. Crespo;A. Crespo;S. Aliño
研究了依赖cAMP的蛋白激酶和蛋白激酶C抑制剂1-(5-isoquinolinylsulfonyl)-2-methylpiperazine H-7、依赖于cAMP和cGMP的蛋白激酶抑制剂n-(2-[methylamino]ethyl)-5-isoquinoline-sulfonamide H-8和环氧合酶抑制剂吲哚美辛对3LL(Lewis肺癌)细胞自发转移能力和抗肿瘤宿主反应的影响。对肿瘤进展的研究表明，H-7和H-8(2 mg kg−1day−1，i.p，连续8天)显著减少了对照组的肺转移数目(分别为0.8±0.2和1.0±0.7，P<0.0 5)。反过来，当动物和肿瘤细胞都用H-8处理时，观察到最高的肿瘤特异性细胞毒性反应(与未治疗的靶细胞相比增加50%)。这表明，蛋白激酶抑制剂可能通过阻断由增加细胞内cAMP的药物触发的免疫抑制机制来抑制肿瘤向肺转移形成的进展。
The effects of 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine H-7 (a cAMP-dependent protein kinase and protein kinase C inhibitor), n-(2-[methylamino]ethyl)-5-isoquinoline-sulfonamide H-8 (a cAMP- and cGMP-dependent protein kinase inhibitor) and indomethacin (IND, a cyclooxygenase inhibitor) on both the spontaneous metastatic ability of 3LL (Lewis lung carcinoma) tumor cells and anti-tumor host response were studied. The study of tumor progression showed that H-7 and H-8 (2 mg kg−1day−1, i.p., for 8 days) significantly reduced the mean number of metastases (0.8±0.2 and 1.0±0.7, respectively, P<0.05) with respect to the number of lung metastases (4.2±2.1) observed in the control group. In turn, the highest tumor-specific cytotoxicity response (50% increase vs. non-treated target cells) was observed when both animal and tumor cells were treated with H-8. This suggests that the protein kinase inhibitors could inhibit tumor progression toward lung metastases formation by blocking the immunosuppressor mechanism triggered by agents that increase intracellular cAMP.
前列腺素E2受体在乳腺肿瘤转移中的作用。
影响因子：
11.2
作者：
Fulton,AM;Zhang,SZ;Chong,YC
通讯作者：
Chong,YC
影响因子：
11.2
作者：
I. Fidler
通讯作者：
I. Fidler
天然效应细胞和前列腺素在控制转移中的相互作用。
DOI：
--
发表时间：
1987
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Fulton,AM
通讯作者：
Fulton,AM