An investigation of the relationship between activation of a social cognitive neural network and social functioning
An investigation of the relationship between activation of a social cognitive neural network and social functioning
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DOI：
10.1093/schbul/sbn031
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发表时间：
2008-07-01
影响因子：
6.6
通讯作者：
Penn, David L.
中科院分区：
文献类型：
--
作者：
Pinkham, Amy E.;Hopfinger, Joseph B.;Penn, David L.
先前在健康个体中研究社会认知的神经生物学基础的工作已经报道了社会认知网络的调节，当个体判断一张脸是不可信的而不是可信的时，杏仁核、梭状回和颞上沟的激活明显增加。我们研究了这种模式是否会出现在精神分裂症患者身上，他们在处理人脸时，这些神经区域的激活程度会降低。此外，我们试图确定这种社会认知网络的调节如何与社会功能相关。神经激活测量使用功能性磁共振成像与血氧水平依赖对比三组个体-精神分裂症的非偏执个体，精神分裂症的偏执个体和健康对照-同时他们将面孔分为值得信赖或不值得信赖。对从感兴趣的先验区域提取的平均信号变化百分比的分析表明，当精神分裂症的控制组和非偏执狂个体认为一张脸不值得信任时，他们对这一社会认知网络的激活程度高于对值得信任的程度。相比之下，偏执狂在对面孔的评价上并没有表现出显著的激活水平差异。此外，这个社会认知网络对不值得信任的面孔的更大激活与社会功能显著正相关。这些发现表明，在处理社会刺激时神经活动的调节受损可能是精神分裂症患者社会认知缺陷和社会功能障碍的基础。
Previous work examining the neurobiological substrates of social cognition in healthy individuals has reported modulation of a social cognitive network such that increased activation of the amygdala, fusiform gyrus, and superior temporal sulcus are evident when individuals judge a face to be untrustworthy as compared with trustworthy. We examined whether this pattern would be present in individuals with schizophrenia who are known to show reduced activation within these same neural regions when processing faces. Additionally, we sought to determine how modulation of this social cognitive network may relate to social functioning. Neural activation was measured using functional magnetic resonance imaging with blood oxygenation level dependent contrast in 3 groups of individuals-nonparanoid individuals with schizophrenia, paranoid individuals with schizophrenia, and healthy controls-while they rated faces as either trustworthy or untrustworthy. Analyses of mean percent signal change extracted from a priori regions of interest demonstrated that both controls and nonparanoid individuals with schizophrenia showed greater activation of this social cognitive network when they rated a face as untrustworthy relative to trustworthy. In contrast, paranoid individuals did not show a significant difference in levels of activation based on how they rated faces. Further, greater activation of this social cognitive network to untrustworthy faces was significantly and positively correlated with social functioning. These findings indicate that impaired modulation of neural activity while processing social stimuli may underlie deficits in social cognition and social dysfunction in schizophrenia.