Angiotensin II type 1 receptor gene polymorphism and telomere shortening in essential hypertension
Angiotensin II type 1 receptor gene polymorphism and telomere shortening in essential hypertension
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DOI：
10.1007/s11010-010-0706-0
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发表时间：
2011-05-01
影响因子：
4.3
通讯作者：
Abdallah, Manal
中科院分区：
文献类型：
--
作者：
Farrag, Wael;Eid, Manal;Abdallah, Manal
在高血压患者中进行了几项遗传学研究，以评估血管紧张素 II 1 型受体基因 3' 非翻译区 1166 位置的等位基因关联。此外，还尝试查明端粒长度损耗是否与高血压相关。本研究的主要目的是检查埃及人血管紧张素 II 1 型受体 A1166C 多态性和端粒长度与原发性高血压的关系。通过 PCR 对 40 名原发性高血压患者和 15 名健康对照者进行血管紧张素 II 1 型基因分型和相对端粒长度研究。研究对象中 AA1166 纯合等位基因频率为 92.8%。血压正常组A等位基因频率无组间变异。高血压患者中纯合 A 等位基因的频率显着高于血压正常者（分别为 97.5% 和 80%），其中男性患者的频率更高。高血压患者的平均端粒长度比显着短于正常人（分别为 1.08 +/- A 0.3 和 1.54 +/- A 0.18）。端粒长度比与体重指数之间没有观察到相关性。这项研究表明，血管紧张素II 1型纯合A1166等位基因和短端粒可能是埃及人原发性高血压的诱发因素，并可能参与该疾病的发病机制。治疗高危患者的进一步策略可能会预防或延迟终末器官损伤。
Several genetic studies were carried out among hypertensive patients to assess allelic association at the 1166 position of the 3' untranslated region of angiotensin II type 1 receptor gene. In addition, attempts have also been made to find out whether telomere length attrition is associated with hypertension. The main aim of this study was to examine the association of A1166C polymorphism of angiotensin II type 1 receptor and telomere length with essential hypertension in Egyptian people. Angiotensin II type 1 genotyping and relative telomere length were investigated by PCR in 40 patients of essential hypertension and 15 healthy controls. The homozygous AA1166 allele frequency was 92.8% among the studied subjects. There was no intergroup variation in A allele frequency in normotensive group. The frequency of homozygous A allele was significantly higher in hypertensive than normotensive subjects (97.5 and 80%, respectively) with higher frequencies in male patients. The average telomere length ratio was significantly shorter in hypertensive than in normal subjects (1.08 +/- A 0.3 and 1.54 +/- A 0.18, respectively). No correlation was observed between telomere length ratio and body mass index. This study suggests that the homozygous A1166 allele of angiotensin II type 1 and short telomeres may be predisposing factors for essential hypertension in Egyptians and may be involved in the pathogenesis of the disease. Further strategies for treating high-risk patients could result in prevention or delay of end organ damage.