Inhalational Gases for Neuroprotection in Traumatic Brain Injury.
Inhalational Gases for Neuroprotection in Traumatic Brain Injury.
复制标题
吸入气体用于创伤性脑损伤的神经保护。
DOI：
10.1089/neu.2021.0053
复制
发表时间：
2021
影响因子：
4.2
通讯作者：
Kilbaugh,ToddJ
中科院分区：
文献类型：
--
作者：
Shin,SamuelS;Hwang,Misun;Diaz-Arrastia,Ramon;Kilbaugh,ToddJ
尽管先前在创伤性脑损伤（TBI）中进行了多项药理学试验，但对这些患者的有效，安全和实用治疗的研究仍在进行中。由于易于输送和快速吸收到体循环中，具有神经保护特性的吸入气体将成为TBI患者临床管理的宝贵资源。在这篇综述中，我们对描述TBI环境中吸入气体治疗的临床前和临床报告进行了系统回顾。本文综述了高压氧的研究历史和最新进展。此外，有前途的新疗法，如氢气，硫化氢气体和一氧化氮进行了讨论。此外，新的疗法，如氙气和氩气和使用微泡输送方法进行了探索。
Despite multiple prior pharmacological trials in traumatic brain injury (TBI), the search for an effective, safe, and practical treatment of these patients remains ongoing. Given the ease of delivery and rapid absorption into the systemic circulation, inhalational gases that have neuroprotective properties will be an invaluable resource in the clinical management of TBI patients. In this review, we perform a systematic review of both pre-clinical and clinical reports describing inhalational gas therapy in the setting of TBI. Hyperbaric oxygen, which has been investigated for many years, and some of the newest developments are reviewed. Also, promising new therapies such as hydrogen gas, hydrogen sulfide gas, and nitric oxide are discussed. Moreover, novel therapies such as xenon and argon gases and delivery methods using microbubbles are explored.