Exploration of 100 commonly used drugs and supplements on cognition in older adults
Exploration of 100 commonly used drugs and supplements on cognition in older adults
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DOI：
10.1016/j.jalz.2012.12.002
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发表时间：
2013-11-01
影响因子：
14
通讯作者：
Roe, Catherine M.
中科院分区：
文献类型：
--
作者：
Obermann, Karen R.;Morris, John C.;Roe, Catherine M.
背景资料：关于药物对认知正常的老年人认知的影响，有相互矛盾的报道，缺乏循证数据。我们探讨了是否使用100种常见药物采取的老年人是与纵向cognitive performance.Methods：一个纵向观察队列与2005年9月至2011年5月收集的数据分析，并保持在国家阿尔茨海默氏症协调中心（NACC）统一的数据集。参与者年龄在50岁或以上，认知正常（N = 4414）。综合评分由10个心理测试构成。计算每个参与者的评分，反映从基线临床评估到下一次评估的心理测量综合评分的变化。一般线性模型被用来测试是否平均复合变化得分不同的参与者报告开始，停止，继续，或不采取每一个100个最常用的药物在NACC sample.Results：评估之间的平均时间为1.2年（SD = 0.42）。从第一次到第二次评估，9种药物在4个参与者组的平均心理测量变化评分中显示出差异（P <0.05）。与心理测量表现改善相关的药物有萘普生、钙-维生素D、硫酸亚铁、氯化钾、亚麻和舍曲林。药物与心理测量性能下降安非他酮，奥昔布宁，和furosemide.Conclusions：报告使用常见的药物与老年人的认知性能，但需要研究调查这些影响的机制。(C)2013年，阿尔茨海默氏症协会。All rights reserved.
Background: There are conflicting reports and a lack of evidence-based data regarding effects of medications on cognition in cognitively normal older adults. We explored whether use of 100 common medications taken by older adults is associated with longitudinal cognitive performance.Methods: A longitudinal observational cohort was used with analysis of data collected from September 2005 through May 2011 and maintained in the National Alzheimer's Coordinating Center (NACC) Uniform Data Set. Participants were aged 50 years or older and cognitively normal (N = 4414). Composite scores were constructed from 10 psychometric tests. Scores for each participant reflecting change in the psychometric composite score from the baseline clinical assessment to the next assessment were calculated. General linear models were used to test whether the mean composite change score differed for participants who reported starting, stopping, continuing, or not taking each of the 100 most frequently used medications in the NACC sample.Results: The average time between assessments was 1.2 years (SD = 0.42). Nine medications showed a difference (P < .05) across the four participant groups in mean psychometric change scores from the first to the second assessment. Medications associated with improved psychometric performance were naproxen, calcium-vitamin D, ferrous sulfate, potassium chloride, flax, and sertraline. Medications associated with declining psychometric performance were bupropion, oxybutynin, and furosemide.Conclusions: Reported use of common medications is associated with cognitive performance in older adults, but studies are needed to investigate the mechanisms underlying these effects. (C) 2013 The Alzheimer's Association. All rights reserved.