Characterization of risk for general population exposure to perfluorooctanoate
Characterization of risk for general population exposure to perfluorooctanoate
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DOI：
10.1016/j.yrtph.2004.03.003
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发表时间：
2004-06-01
影响因子：
3.4
通讯作者：
Zobel, LR
中科院分区：
文献类型：
--
作者：
Butenhoff, JL;Gaylor, DW;Zobel, LR
全氟辛酸（PFOA）是一种环境和代谢稳定的全氟羧酸，已在美国儿童、成人和老年人的血清中检测到，第95百分位数估计值的上限范围为0.011-0.014微克/毫升（ppm）。在该风险表征中，通过比较一般人群血清PFOA浓度与毒理学研究中的血清浓度，确定了暴露范围（莫伊），该暴露范围可以提供对人类风险潜力的现实观点，毒理学研究与使用USEPA BMDS软件模拟的10%响应或发生率水平（LBMIC 10）的95%置信下限相关。如果血清PFOA数据不可用，则使用其他研究的替代数据或药代动力学关系估计LBMIC 10。模拟的剂量反应（LBMIC 10值）包括大鼠的出生后效应（29 mug/mL）、大鼠和猴的肝脏重量增加（23 mug/mL）和体重变化（60 mug/mL）以及大鼠Leydig细胞腺瘤的发生率（125 mug/mL）。基于第95百分位数人群血清PFOA浓度上限的莫伊值较大，范围从1600（肝脏重量增加）至8900（间质细胞腺瘤）。这些莫伊值代表了对儿童、成人和老年人的实质性保护。(C)2004年爱思唯尔公司All rights reserved.
Perfluorooctanoate (PFOA), an environmentally and metabolically stable perfluorinated carboxylic acid, has been detected in the serum of children, adults and the elderly from the United States with the upper bound of the 95th percentile estimate in the range of 0.011-0.014 mug/mL (ppm). In this risk characterization, margins of exposure (MOE), which can provide a realistic perspective on potential for human risk, were determined by comparison of general population serum PFOA concentrations with serum concentrations from toxicological studies that are associated with the lower 95% confidence limit of a modeled 10 percent response or incidence level (LBMIC10) using USEPA BMDS software. The LBMIC10 was estimated using surrogate data from other studies or pharmacokinetic relationships if serum PFOA data were not available. Modeled dose-responses (with resulting LBMIC10 values) included post-natal effects in rats (29 mug/mL), liver-weight increase (23 mug/mL), and body-weight change (60 mug/mL) in rats and monkeys, and incidence of Leydig cell adenoma (125 mug/mL) in rats. MOE values based on the upper bound 95th percentile population serum PFOA concentration were large, ranging from 1600 (liver-weight increase) to 8900 (Leydig cell adenoma). These MOE values represent substantial protection of children, adults, and the elderly. (C) 2004 Elsevier Inc. All rights reserved.