Effect of episodic hypoxia on upper airway mechanics in humans during NREM sleep.
Effect of episodic hypoxia on upper airway mechanics in humans during NREM sleep.
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间歇性缺氧对 NREM 睡眠期间人类上气道力学的影响。
DOI：
10.1152/japplphysiol.00938.2001
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发表时间：
2002
期刊：
影响因子：
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通讯作者：
Badr,MSafwan
中科院分区：
文献类型：
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作者：
Shkoukani,Mahdi;Babcock,MarkA;Badr,MSafwan
我们假设长期促进(LTF)是由于上呼吸道阻力(RUA)降低所致。我们研究了11名正常受试者在稳定的非快速眼动睡眠中的情况。我们诱导短暂的等颅压低氧(吸入氧气分数=8%)(3min)，然后是室内空气5min。这个序列重复了10次。在对照组、缺氧组和恢复20分钟(R20)时测量通气量、计时和RUA。此外，9名受试者在没有低氧暴露的情况下进行了假研究。在间歇性低氧研究中，吸气每分钟通气量(V·I)由对照组的7.1±1.8 L/分钟增加到R20时的8.3±1.8 L/分钟(为对照组的117%，P<0.0 5)。而对照组(16.1±6.9个任意单位)和R20(15.3±4.9个任意单位)(95%的对照组；P>；0.05)无明显变化。相反，V·i的增加伴随着Ra的降低，从对照组的10.7±7.5cmH2O·L−1·S下降到R20时的8.2±4.4cmH2O·L−1·S(对照组的77%；P<；0.05)。在假研究期间，与对照组相比，恢复期的V·I、RuA或EMG没有变化。我们得出以下结论：1)恢复期V·i增加预示着LTF，2)EMG缺乏增加提示隔膜缺乏LTF，3)RuA减少提示上呼吸道扩张器的LTF，4)恢复期V·i增加是由于上呼吸道扩张器的LTF“卸载”上呼吸道所致。
We hypothesized that long-term facilitation (LTF) is due to decreased upper airway resistance (Rua). We studied 11 normal subjects during stable non-rapid eye movement sleep. We induced brief isocapnic hypoxia (inspired O2fraction = 8%) (3 min) followed by 5 min of room air. This sequence was repeated 10 times. Measurements were obtained during control, hypoxia, and at 20 min of recovery (R20) for ventilation, timing, and Rua. In addition, nine subjects were studied in a sham study with no hypoxic exposure. During the episodic hypoxia study, inspiratory minute ventilation (V˙i) increased from 7.1 ± 1.8 l/min during the control period to 8.3 ± 1.8 l/min at R20(117% of control;P< 0.05). Conversely, there was no change in diaphragmatic electromyogram (EMGdia) between control (16.1 ± 6.9 arbitrary units) and R20(15.3 ± 4.9 arbitrary units) (95% of control;P> 0.05). In contrast, increasedV˙iwas associated with decreased Rua from 10.7 ± 7.5 cmH2O · l−1· s during control to 8.2 ± 4.4 cmH2O · l−1· s at R20(77% of control;P< 0.05). No change was noted in V˙i, Rua, or EMGdiaduring the recovery period relative to control during the sham study. We conclude the following:1) increased V˙iin the recovery period is indicative of LTF,2) the lack of increased EMGdiasuggests lack of LTF to the diaphragm,3) reduced Rua suggests LTF of upper airway dilators, and4) increased V˙iin the recovery period is due to “unloading” of the upper airway by LTF of upper airway dilators.