The hippocampus, prefrontal cortex, and perirhinal cortex are critical to incidental order memory
The hippocampus, prefrontal cortex, and perirhinal cortex are critical to incidental order memory
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DOI：
10.1016/j.bbr.2019.112215
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发表时间：
2020-02-03
影响因子：
2.7
通讯作者：
Fortin, Norbert J.
中科院分区：
文献类型：
--
作者：
Allen, Leila M.;Lesyshyn, Rachel A.;Fortin, Norbert J.
对啮齿动物和人类的大量研究表明，海马和前额叶皮层对于记忆刺激之间的时间关系至关重要，越来越多的证据表明，嗅周皮层也可能参与其中。然而，不同研究的实验参数差异很大，这限制了我们充分理解这些结构的基本贡献的能力。事实上，以前的研究在他们强调的时间记忆类型上各不相同（例如，顺序、序列或时间上的分离），它们使用的刺激和响应（例如，试验唯一或重复序列，以及偶然或奖励行为），以及它们控制潜在混杂因素的程度（例如，主要和近因效应，或顺序记忆缺陷继发于项目记忆障碍）。为了帮助整合这些发现，我们开发了一种新的范式，测试试验独特的一系列事件的偶然记忆，并同时评估海马体，前额叶皮层或嗅周皮层受损的动物的顺序和项目记忆。我们发现，这种新的方法导致了强大的顺序和项目的记忆，海马，前额叶和嗅周损伤选择性地损害顺序记忆。这些发现表明，海马体、前额叶皮层和嗅周皮层是一个广泛的结构网络的一部分，这些结构对偶然学习情景记忆中事件的顺序至关重要。
Considerable research in rodents and humans indicates the hippocampus and prefrontal cortex are essential for remembering temporal relationships among stimuli, and accumulating evidence suggests the perirhinal cortex may also be involved. However, experimental parameters differ substantially across studies, which limits our ability to fully understand the fundamental contributions of these structures. In fact, previous studies vary in the type of temporal memory they emphasize (e.g., order, sequence, or separation in time), the stimuli and responses they use (e.g., trial-unique or repeated sequences, and incidental or rewarded behavior), and the degree to which they control for potential confounding factors (e.g., primary and recency effects, or order memory deficits secondary to item memory impairments). To help integrate these findings, we developed a new paradigm testing incidental memory for trial-unique series of events, and concurrently assessed order and item memory in animals with damage to the hippocampus, prefrontal cortex, or perirhinal cortex. We found that this new approach led to robust order and item memory, and that hippocampal, prefrontal and perirhinal damage selectively impaired order memory. These findings suggest the hippocampus, prefrontal cortex and perirhinal cortex are part of a broad network of structures essential for incidentally learning the order of events in episodic memory.