Studies on Scutellariae radix. XII. Anti-thrombic actions of various flavonoids from Scutellariae radix.
Studies on Scutellariae radix. XII. Anti-thrombic actions of various flavonoids from Scutellariae radix.
复制标题
黄芩的研究。
DOI：
10.1248/cpb.33.2411
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发表时间：
1985
影响因子：
1.7
通讯作者：
H. Okuda
中科院分区：
文献类型：
--
作者：
M. Kubo;H. Matsuda;T. Tani;S. Arichi;Y. Kimura;H. Okuda
从黄芩根中提取黄芩苷、黄芩苷、黄芩苷、黄芩苷-7- o - d -葡萄糖醛酸盐、oroxylin A、黄芩黄酮II、大黄素、(2S)-2′、5,6′、7-四羟基黄酮和(2R, 3R)-2′、3,5,6′、7-五羟基黄酮，并与阿司匹林和肝素两种标准抗血栓药进行比较，筛选黄芩苷类黄酮在血小板聚集或纤维蛋白原转化为纤维蛋白的实验模型中的活性。1.0 mM浓度的黄芩苷、枸杞子苷、oroxylin A、黄酮II和黄菊花素对胶原诱导的血小板聚集有抑制作用。黄菊花素还能抑制二磷酸腺苷（ADP）诱导的血小板聚集。在花生四烯酸诱导血小板聚集的情况下，黄芩素和枸杞子素被发现有抑制作用。黄芩素和黄芩苷抑制凝血酶诱导的纤维蛋白原向纤维蛋白的转化。观察黄芩素和黄芩苷对内毒素致大鼠弥散性血管内凝血（DIC）的影响；两种化合物均能防止DIC大鼠血小板和纤维蛋白原的减少。
The flavonoid components, baicalein, baicalin, wogonin, wogonin-7-O-D-glucuronide, oroxylin A, skullcapflavone II, chrysin, (2S)-2', 5, 6', 7-tetrahydroxyflavanone and (2R, 3R)-2', 3, 5, 6', 7-pentahydroxyflavanone, obtained from the roots of Scutellaria baicalensis have been screened in comparison with two standard anti-thrombic agents, aspirin and heparin, for activity in experimental models of blood platelet aggregation or conversion of fibrinogen to fibrin. Baicalein, wogonin, oroxylin A, skullcapflavone II and chrysin at a concentration of 1.0 mM inhibited collagen-induced blood platelet aggregation. Chrysin was also found to inhibit adenosine diphosphate (ADP)-induced blood platelet aggregation. In the case of arachidonic acid-induced blood platelet aggregation, baicalein and wogonin were found to have an inhibitory action. Baicalein and baicalin among the test substances inhibited the conversion of fibrinogen to fibrin induced by thrombin. The effects of baicalein and baicalin on the experimental disseminated intravascular coagulation (DIC) induced by endotoxin in rats was examined ; both compounds prevented the decrease of blood platelets and fibrinogen in DIC rats.