Atypical exocrine and endocrine pancreatic tumors (anaplastic, small cell, and giant cell types): CT and pathologic features in 14 patients
Atypical exocrine and endocrine pancreatic tumors (anaplastic, small cell, and giant cell types): CT and pathologic features in 14 patients
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DOI：
10.1007/s002610000058
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发表时间：
2000-07-01
影响因子：
--
通讯作者：
Araki, T
中科院分区：
文献类型：
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作者：
Ichikawa, T;Federle, MP;Araki, T
背景：我们的目的是回顾一系列不典型的胰腺外分泌和内分泌肿瘤患者的CT和病理特征，以便更好地诊断、分类和处理这些患者。方法：回顾几所大学医学中心的病历。结果：我们发现了三种不同类型的胰腺肿瘤，它们具有显著不同的形态和预后特征。在这些罕见的肿瘤中，间变性癌是最常见的(14例中的9例)，这些肿瘤很大，部分坏死，局部侵袭，在诊断时总是转移(淋巴结和/或肝脏)。3例低分化(小细胞)癌患者胰腺肿块和淋巴结融合，但无导管阻塞，与淋巴瘤或转移性疾病相似。2例巨细胞(破骨细胞样)癌患者有一个大的、包膜的多囊性肿瘤伴出血，这些肿瘤是可以切除治疗的。结论：虽然在某些病例中可能不能做出特定的诊断，但我们相信了解某些病理和计算机断层扫描特征将有助于最佳的诊断、治疗和预后。
Background: Our purpose was to review a series of 14 patients with atypical exocrine and endocrine pancreatic tumors to derive characteristic computed tomographic and pathologic features that might allow better diagnosis, categorization, and management of these patients.Methods: Medical records from several university medical centers were reviewed retrospectively.Results: We identified three separate types of pancreatic tumors that had substantially different morphologic and prognostic features. Among these rare tumors, anaplastic carcinoma was the most common (nine of 14 cases), and these tumors were large, partly necrotic, locally invasive, and invariably metastatic (lymph nodes and/or liver) at the time of diagnosis. Three patients with poorly differ entiated (small cell) carcinoma had a confluent pancreatic mass and lymphadenopathy but no ductal obstruction, closely resembling lymphoma or metastatic disease. Two patients with giant cell (osteoclastlike) carcinoma had a large, encapsulated multicystic tumor with hemorrhage, and these tumors were resectable for cure.Conclusion: Although a specific diagnosis may not be possible in some cases, we believe that knowledge of certain pathologic and computed tomographic features should lead to optimal diagnosis, therapy, and prognosis.