Effect of genetic polymorphism of OATP-C (SLCO1B1) on lipid-lowering response to HMG-CoA reductase inhibitors.
Effect of genetic polymorphism of OATP-C (SLCO1B1) on lipid-lowering response to HMG-CoA reductase inhibitors.
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DOI：
10.2133/dmpk.19.375
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发表时间：
2004-10-01
影响因子：
2.1
通讯作者：
Miki, Tetsuro
中科院分区：
文献类型：
--
作者：
Tachibana-Iimori, Rieko;Tabara, Yasuharu;Miki, Tetsuro
研究了人有机阴离子转运多肽C（OATP-C）基因多态性对3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶抑制剂降脂效应的影响。对日本南部爱媛县一家市立医院的66例接受HMG-CoA还原酶抑制剂治疗的高脂血症患者进行了一项回顾性研究。分析了给药前后患者的血脂浓度与OATP-C基因521 T/C（瓦尔-174-->Ala）多态性的关系（TT：n=44（66.7%），TC：n=20（30.3%），CC：n=0（0.0%），未确定：n=2（3.0%））。在所有患者中，HMG-CoA还原酶抑制剂治疗后总胆固醇水平显著降低（p
The effect of genetic polymorphism of human organic anion transporting polypeptide C (OATP-C) on the lipid-lowering response to 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitors was assessed. A retrospective study was conducted on 66 patients who underwent treatment of hyperlipidemia with HMG-CoA reductase inhibitors in a municipal hospital in a community-based cohort of Ehime prefecture in the southern part of Japan. Plasma lipid concentrations before and after administration were analyzed in patients in relation to the 521T/C (Val-174-->Ala) polymorphism in the OATP-C gene (TT: n=44 (66.7%), TC: n=20 (30.3%), CC: n=0 (0.0%), undetermined: n=2 (3.0%)). Total cholesterol level was significantly lowered after treatment with HMG-CoA reductase inhibitors in all patients (p