Noncontact stimulation of the cavernous nerves in the rat prostate using a tunable-wavelength thulium fiber laser
Noncontact stimulation of the cavernous nerves in the rat prostate using a tunable-wavelength thulium fiber laser
复制标题
DOI：
10.1089/end.2008.9996
复制
发表时间：
2008-03-01
影响因子：
2.7
通讯作者：
Burnett, Arthur L.
中科院分区：
文献类型：
--
作者：
Fried, Nathaniel M.;Lagoda, Gwen A.;Burnett, Arthur L.
背景和目的：激光神经刺激最近在神经科学中作为电刺激的替代方案进行了研究。其优点包括非接触式刺激、更好的空间选择性以及消除电刺激伪影。本研究探讨了在保留神经的根治性前列腺切除术中，激光刺激大鼠海绵体神经作为电神经标测的潜在替代方案。材料和方法：通过手术暴露 10 只雄性大鼠的海绵体神经。采用铥光纤激光刺激神经，波长为1870nm，脉冲能量为7.5 mJ，辐射量为1 J/cm(2)，脉冲持续时间为2.5 msec，脉冲频率为10 Hz，激光光斑直径为1 mm，刺激时间为60 sec。结果与结论：激光刺激时检测到海绵体内压力显着增加，刺激后压力恢复到基线值停止了。这项研究证明了使用近红外激光辐射非接触刺激海绵体神经的可行性。
Background and Purpose: Laser nerve stimulation has recently been studied in neuroscience as an alternative to electrical stimulation. Its advantages include noncontact stimulation, better spatial selectivity, and elimination of electrical stimulation artifacts. This study explored laser stimulation of the rat cavernous nerves as a potential alternative to electrical nerve mapping during nerve-sparing radical prostatectomy.Materials and Methods: The cavernous nerves were surgically exposed in 10 male rats. A thulium fiber laser stimulated the nerves, with a wavelength of 1870 run, pulse energy of 7.5 mJ, radiant exposure of 1 J/cm(2), pulse duration of 2.5 msec, pulse rate of 10 Hz, and 1-mm laser spot diameter, for a stimulation time of 60 sec.Results and Conclusion: A significant increase in the intracavernosal pressure was detected on laser stimulation, with pressure returning to baseline values after stimulation ceased. This study demonstrates the feasibility of noncontact stimulation of the cavernous nerves using near-infrared laser radiation.