Temporomandibular disorder and optimism: relationships to ischemic pain sensitivity and interleukin-6
Temporomandibular disorder and optimism: relationships to ischemic pain sensitivity and interleukin-6
复制标题
DOI：
10.1016/s0304-3959(02)00263-4
复制
发表时间：
2002-11-01
期刊：
影响因子：
7.4
通讯作者：
Maixner, W
中科院分区：
文献类型：
--
作者：
Costello, NL;Bragdon, EE;Maixner, W
目前的研究检查颞下颌关节紊乱病（TMD）患者（n = 20）和无痛对照组（n = 28）在应力和放松条件下。白细胞介素-6（IL-6），去甲肾上腺素和肾上腺素（NE和E）的测量之前和期间的两个条件：一个非压力放松期和言语应激。在这些条件中的每一个之后还评估了缺血性疼痛敏感性。乐观（生活取向测试（LOT）），这与健康和疾病的关系更好的结果，也评估了与缺血性疼痛耐受性和不愉快的评级以及IL-6水平在两种条件下的关系。回归分析确定了每个预测因子的独特贡献，以及在控制性别和血压后，乐观与群体（TMD与对照组）之间的相互作用。在应激期间，IL-6水平似乎与NE平行，仅对照显示显著增加。在控制了抑郁情绪后，与对照组相比，TMD患者作为一个整体在应激期间产生的IL-6水平中显示出显著迟钝的反应（β = 0.31*）。虽然TMD受试者作为一个整体并没有表现出预期的更大的疼痛敏感性，缺血任务，那些表现出不太乐观的风格确实表现出较低的疼痛耐受时间（β = -0.61 *）和较高的疼痛不愉快的评级（β = 0.48*），与低乐观的控制和高乐观的TMD患者。不太乐观的TMD患者在应激时NE和IL-6水平也高于其他TMD患者，而乐观与对照组的反应无关（*P < 0.05）。(C)2002年国际疼痛研究协会。由Elsevier Science B. V.出版，版权所有。
The current study examined patients with temporomandibular disorders (TMD) (n = 20) and pain-free controls (n = 28) under stress and relaxation conditions. Interleukin-6 (IL-6), norepinephrine and epinephrine (NE and E) were measured both before and during each of two conditions: a non-stressful relaxation period and a speech stressor. Ischemic pain sensitivity was also assessed after each of these conditions. Optimism (Life Orientation Test (LOT)), which has been associated with better outcomes in relationship to health and disease, was also evaluated in relationship to ischemic pain tolerance and unpleasantness ratings as well as to IL-6 levels under the two conditions. Regression analysis determined the unique contribution of each predictor and the interaction between Optimism and Group (TMD versus controls) after controlling for gender and blood pressure. During stress, IL-6 levels appeared to parallel NE with only controls displaying significant increases. After controlling for depressed mood, TMD patients as a whole showed a significantly blunted response in IL-6 levels produced during stress as compared to controls beta = 0.31*). Although TMD subjects as a whole did not show the expected greater pain sensitivity to the ischemic task, those displaying a less optimistic style did exhibit lower pain tolerance times (beta = -0.61 *) and higher pain unpleasantness ratings (beta = 0.48*), compared with low optimism controls and high optimism TMD patients. Less optimistic TMD patients also had higher NE and IL-6 levels during stress than other TMD patients, while optimism was unrelated to responses in controls (*P < 0.05). (C) 2002 International Association for the Study of Pain. Published by Elsevier Science B.V. All rights reserved.