Biogenic synthesis, characterization, acute oral toxicity studies of synthesized Ag and ZnO nanoparticles using aqueous extract of Lawsonia inermis
Biogenic synthesis, characterization, acute oral toxicity studies of synthesized Ag and ZnO nanoparticles using aqueous extract of Lawsonia inermis
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DOI：
10.1016/j.matlet.2017.09.082
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发表时间：
2018-01-15
影响因子：
3
通讯作者：
Rajendar, V.
中科院分区：
文献类型：
--
作者：
Jayarambabu, N.;Rao, K. Venkateswara;Rajendar, V.
采用绿色方法，以Lawsonia inermis植物提取物为原料，合成了Ag和ZnO纳米粒子。在Lawsonia inermis叶提取物中发现的植物化学成分（2-羟基-1，4-萘醌）在Ag和ZnO纳米颗粒的还原和形成中起重要作用。通过从无色到深棕色和浅棕色的颜色变化来观察Ag和ZnO纳米颗粒的生物合成。FE SEM、TEM DLS分析证实Ag和ZnO纳米颗粒的平均粒径分别为100 nm、20 nm、28.5 nm和100 nm、20 nm、38.4 nm。通过XRD证实了Ag和ZnO NP的结晶性质和存在。FT-IR光谱的银和ZnO授权的植物成分作为封端剂的存在。根据急性口服毒性研究的结果，发现2000 mg/kg B.w的Ag和ZnO NP在治疗期间没有显示死亡。本研究揭示了环境友好的绿色合成银和氧化锌纳米粒子在纳米生物医学领域的安全使用。(C)2017爱思唯尔B. V.保留所有权利。
The Ag and ZnO nanoparticles are synthesized by a green method using Lawsonia inermis plant extract. The phytochemical constituent (2-hydroxy-1, 4-napthoquionone) found in the leaf extract of Lawsonia inermis plays an important role in the reduction and formation of Ag and ZnO nanoparticles. The biosynthesis of Ag and ZnO NPs was observed by the color change from colorless to dark brown and light brown. The FE SEM, TEM DLS analysis confirmed the average particle size of Ag and ZnO NPs as 100 nm, 20 nm, 28.5 nm and 100 nm, 20 nm, 38.4 nm respectively. Crystalline nature and presence of Ag and ZnO NPs were confirmed by XRD. The FT-IR spectra of the Ag and ZnO authorized the presence of phyto constituents as capping agent. From results of acute oral toxicity studies, it was found that Ag and ZnO NPs at 2000 mg/kg b.w have shown no mortality during the treatment period. The present study revealed the safer use of eco-friendly green synthesized Ag and ZnO NPs in the field of nano-biomedicine. (C) 2017 Elsevier B.V. All rights reserved.