Dosimetric comparison of carbon ion and X-ray radiotherapy for Stage IIIA non-small cell lung cancer.
Dosimetric comparison of carbon ion and X-ray radiotherapy for Stage IIIA non-small cell lung cancer.
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DOI：
10.1093/jrr/rrw041
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发表时间：
2016-09
影响因子：
2
通讯作者：
Nakano T
中科院分区：
文献类型：
--
作者：
Kubo N;Saitoh JI;Shimada H;Shirai K;Kawamura H;Ohno T;Nakano T
本研究比较了IIIA期非小细胞肺癌（NSCLC）患者接受碳离子放疗与x射线放疗的剂量-体积直方图。入选IIIA期NSCLC患者（每种入路n = 10例）。两种放疗方案在同一CT上计算相同的靶和危险器官。预防性淋巴结及原发肿瘤（PTV1）治疗方案x射线放疗40 Gy，碳离子放疗40 Gy（相对生物有效性，RBE）。原发肿瘤及临床阳性淋巴结（PTV2）放疗总剂量为x线放疗60 Gy，碳离子放疗60 Gy （RBE）。碳离子放疗中PTV1和PTV2的均匀性指标优于x线放疗（PTV1, 0.57 vs 0.65, P = 0.009; PTV2, 0.07 vs 0.16, P = 0.005）。碳离子放疗的正常肺平均剂量、V5、V10和V20分别为7.7 Gy （RBE）、21.4%、19.7%和17.0%，而x射线放疗的相应剂量分别为11.9 Gy、34.9%、26.6%和20.8%。碳离子放疗组脊髓最大剂量、食管最大剂量及V50、骨V10、V30、V50均低于x线放疗组。目前的研究表明，与x射线放疗相比，碳离子放疗对IIIA期非小细胞肺癌的靶剂量更均匀，对危险器官的剂量更低。
The present study compared the dose–volume histograms of patients with Stage IIIA non–small cell lung cancer (NSCLC) treated with carbon ion radiotherapy with those of patients treated with X-ray radiotherapy. Patients with Stage IIIA NSCLC (n = 10 patients for each approach) were enrolled. Both radiotherapy plans were calculated with the same targets and organs at risk on the same CT. The treatment plan for the prophylactic lymph node and primary tumor (PTV1) delivered 40 Gy for X-ray radiotherapy and 40 Gy (relative biological effectiveness; RBE) for carbon ion radiotherapy. The total doses for the primary tumor and clinically positive lymph nodes (PTV2) were 60 Gy for X-ray radiotherapy and 60 Gy (RBE) for carbon ion radiotherapy. The homogeneity indexes for PTV1 and PTV2 were superior for carbon ion radiotherapy in comparison with X-ray radiotherapy (PTV1, 0.57 vs 0.65, P = 0.009; PTV2, 0.07 vs 0.16, P = 0.005). The normal lung mean dose, V5, V10 and V20 for carbon ion radiotherapy were 7.7 Gy (RBE), 21.4%, 19.7% and 17.0%, respectively, whereas the corresponding doses for X-ray radiotherapy were 11.9 Gy, 34.9%, 26.6% and 20.8%, respectively. Maximum spinal cord dose, esophageal maximum dose and V50, and bone V10, V30 and V50 were lower with carbon ion radiotherapy than with X-ray radiotherapy. The present study indicates that carbon ion radiotherapy provides a more homogeneous target dose and a lower dose to organs at risk than X-ray radiotherapy for Stage IIIA non–small cell lung cancer.
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影响因子：
51.1
作者：
Bradley, Jeffrey D.;Paulus, Rebecca;Komaki, Ritsuko;Masters, Gregory;Blumenschein, George;Schild, Steven;Bogart, Jeffrey;Hu, Chen;Forster, Kenneth;Magliocco, Anthony;Kavadi, Vivek;Garces, Yolanda I.;Narayan, Samir;Iyengar, Puneeth;Robinson, Cliff;Wynn, Raymond B.;Koprowski, Christopher;Meng, Joanne;Beitler, Jonathan;Gaur, Rakesh;Curran, Walter, Jr.;Choy, Hak
通讯作者：
Choy, Hak
DOI：
10.1016/j.ijrobp.2009.06.091
发表时间：
2010-03-01
影响因子：
7
作者：
Marks, Lawrence B.;Bentzen, Soren M.;Deasy, Joseph O.;Kong, Feng-Ming (Spring);Bradley, Jeffrey D.;Vogelius, Ivan S.;El Naqa, Issam;Hubbs, Jessica L.;Lebesque, Joos V.;Timmerman, Robert D.;Martel, Mary K.;Jackson, Andrew
通讯作者：
Jackson, Andrew
影响因子：
3.6
作者：
Nichols, R. Charles;Huh, Soon N.;Hoppe, Bradford S.
通讯作者：
Hoppe, Bradford S.
DOI：
10.1016/j.ijrobp.2006.01.052
发表时间：
2006-07-15
影响因子：
7
作者：
Chang, Joe Y.;Zhang, Xiaodong;Cox, James D.
通讯作者：
Cox, James D.
DOI：
10.1016/j.ijrobp.2007.08.005
发表时间：
2008-03-15
影响因子：
7
作者：
Oh, Dongryul;Huh, Seung Jae;Lee, Je Ho
通讯作者：
Lee, Je Ho