Rotating night shifts and risk of skin cancer in the nurses' health study.
Rotating night shifts and risk of skin cancer in the nurses' health study.
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护士健康研究中的夜班轮班与皮肤癌风险。
DOI：
10.1093/jnci/djr044
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Han,Jiali
中科院分区：
文献类型：
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作者：
Schernhammer,EvaS;Razavi,Pedram;Li,TriciaY;Qureshi,AbrarA;Han,Jiali
夜班工作与几种癌症的风险增加有关，但夜班工人患皮肤癌的风险尚不清楚。我们在1988年6月至2006年6月的护士健康研究中记录了68336名女性中的10799例皮肤癌事件，并研究了夜班轮换与皮肤癌之间的关系。我们使用考克斯比例风险模型，调整混杂变量（皮肤癌的表型和既定风险因素），并进行分层分析以探索头发颜色的改变作用。与从不上夜班的人相比，上夜班10年或更长时间的人患皮肤癌的风险降低了14（年龄标准化发病率：分别为976/100 000人-年（PY）和1070/100 000 PY;校正的危险比= 0.86，95%置信区间= 0.81 ~ 0.92，P趋势< .001）。这种关联在皮肤黑色素瘤中最强;在调整黑色素瘤危险因素后，（年龄标准化发病率：分别为20/100 000 PY和35/100 000 PY;校正的危险比= 0.56，95%置信区间= 0.36 ~ 0.87，Ptrend = .005）。头发颜色，一个人的皮肤癌易感性的替代品，是一个统计学上显着的影响因素，观察到的协会;深色头发的妇女有最低的风险（P互动= 0.02）。
Night shift work is associated with increased risk of several cancers, but the risk of skin cancer among night shift workers is unknown. We documented 10 799 incident skin cancers in 68 336 women in the Nurses’ Health Study from June 1988 to June 2006 and examined the relationship between rotating night shifts and skin cancer. We used Cox proportional hazard models, adjusted for confounding variables (phenotypic and established risk factors of skin cancer), and performed stratified analysis to explore the modifying effect of hair color. Working 10 years or more on rotating night shifts was associated with a 14% decreased risk of skin cancer compared with never working night shifts (age-standardized incidence rate: 976 per 100 000 person-years (PY) vs 1070 per 100 000 PY, respectively; adjusted hazard ratios = 0.86, 95% confidence interval = 0.81 to 0.92,Ptrend< .001). This association was strongest for cutaneous melanoma; working 10 years or more of rotating night shifts was associated with 44% decreased risk of melanoma, after adjustment for melanoma risk factors (age-standardized incidence rate: 20 per 100 000 PY vs 35 per 100 000 PY, respectively; adjusted hazard ratios = 0.56, 95% confidence interval = 0.36 to 0.87,Ptrend= .005). Hair color, a surrogate for an individual’s susceptibility to skin cancer, was a statistically significant effect modifier for the observed associations; darker-haired women had the lowest risk (Pinteraction= .02).