Abnormal response to methylphenidate across multiple fMRI procedures in cocaine use disorder: feasibility study.
Abnormal response to methylphenidate across multiple fMRI procedures in cocaine use disorder: feasibility study.
复制标题
可卡因使用障碍中多个功能磁共振成像程序对哌醋甲酯的异常反应：可行性研究。
DOI：
10.1007/s00213-016-4307-9
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发表时间：
2016
影响因子：
3.4
通讯作者：
Goldstein,RitaZ
中科院分区：
文献类型：
--
作者：
Moeller,ScottJ;Konova,AnnaB;Tomasi,Dardo;Parvaz,MuhammadA;Goldstein,RitaZ
间接多巴胺激动剂哌甲酯治疗精神病理学中的认知缺陷，但决定其对大脑影响的个体特征尚不清楚。目的我们旨在确定是否有针对性的多巴胺能调节特征和个体差异可以预测多种功能磁共振成像（fMRI）程序对哌甲酯的神经反应。方法我们结合了三种不同程序的神经测量（两个抑制控制任务的情绪显着性和静息状态功能连接的程度不同）在哌醋甲酯（20 mg口服，对比随机和平衡安慰剂），并将这些聚集反应与可卡因使用障碍诊断相关联（22名可卡因滥用者，21名对照），注意缺陷多动障碍的症状，和工作记忆能力。相对于对照组，在所有三个程序中，背外侧前额叶皮层对哌甲酯的反应较低，这是由对两个抑制控制任务的反应驱动的;该区域哌甲酯fMRI反应降低与更频繁的可卡因使用进一步相关。（及其频率），与较低的紧张性多巴胺水平相关，与哌醋甲酯激活减少相关（与安慰剂相比）。这些初步的结果提供了可行性的想法，多模态功能磁共振成像任务可以有意义地聚合，这些聚合的程序显示了一个共同的中断成瘾在一个高度期待的区域相关的认知控制。研究结果还表明，药物使用频率可能是一个重要的调节变量，在解释成瘾的认知干预措施的有效性。
RationaleThe indirect dopamine agonist methylphenidate remediates cognitive deficits in psychopathology, but the individual characteristics that determine its effects on the brain are not known.ObjectivesWe aimed to determine whether targeted dopaminergically modulated traits and individual differences could predict neural response to methylphenidate across multiple functional magnetic resonance imaging (fMRI) procedures.MethodsWe combined neural measures from three separate procedures (two inhibitory control tasks differing in their degree of emotional salience and resting-state functional connectivity) during methylphenidate (20 mg oral, versus randomized and counterbalanced placebo) and correlated these aggregated responses with cocaine use disorder diagnosis (22 cocaine abusers, 21 controls), symptoms of attention deficit hyperactivity disorder, and working memory capacity.ResultsCocaine abusers, relative to controls, had a lower response in the dorsolateral prefrontal cortex to methylphenidate across all three procedures, driven by responses to the two inhibitory control tasks; reduced methylphenidate fMRI response in this region further correlated with more frequent cocaine use.ConclusionsCocaine abuse (and its frequency), associated with lower tonic dopamine levels, correlated with a reduction in activation to methylphenidate (versus placebo). These initial results provide feasibility to the idea that multimodal fMRI tasks can be meaningfully aggregated, and that these aggregated procedures show a common disruption in addiction in a highly anticipated region relevant to cognitive control. Results also suggest that drug use frequency may represent an important modulatory variable in interpreting the efficacy of pharmacologically enhanced cognitive interventions in addiction.