A NEW CLASS OF STEROIDS INHIBITS ANGIOGENESIS IN THE PRESENCE OF HEPARIN OR A HEPARIN FRAGMENT
A NEW CLASS OF STEROIDS INHIBITS ANGIOGENESIS IN THE PRESENCE OF HEPARIN OR A HEPARIN FRAGMENT
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DOI：
10.1126/science.2416056
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发表时间：
1985-01-01
期刊：
影响因子：
56.9
通讯作者：
FOLKMAN, J
中科院分区：
文献类型：
--
作者：
CRUM, R;SZABO, S;FOLKMAN, J
发现缺乏糖皮质激素或盐皮质激素活性的类固醇在肝素或特异性肝素片段存在下抑制血管生成。这种新发现的类固醇功能似乎是由不同的结构配置的甾烷核。这些化合物在这里被称为血管抑制类固醇。
Steroids that lack glucocorticoid or mineralocorticoid activity were found to inhibit angiogenesis in the presence of heparin or specific heparin fragments. This newly discovered steroid function appears to be governed by distinct structural configurations of the pregnane nucleus. These compounds are here named angiostatic steroids.