Common Data Elements in the Assessment of Military-Related PTSD Research Applied in the Consortium to Alleviate PTSD
Common Data Elements in the Assessment of Military-Related PTSD Research Applied in the Consortium to Alleviate PTSD
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DOI：
10.1093/milmed/usy226
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发表时间：
2019-05-01
影响因子：
1.2
通讯作者：
Taylor, Daniel J.
中科院分区：
文献类型：
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作者：
Ben Barnes, J.;Presseau, Candice;Taylor, Daniel J.
导言：在共享数据、充分支持研究并允许医学和精神疾病的交叉研究比较的需求的推动下，总统于2013年发布的国家研究行动计划呼吁使用最先进的公共数据元素(CDE)进行研究。CDE是在独立研究中测量的变量，有助于在方法上合理的数据汇总和研究复制。与军事相关的创伤后应激障碍(PTSD)领域的研究人员已经提出了适用的CDE；然而，到目前为止，这些建议还只是概念性的，没有经过现场测试。缓解创伤后应激障碍联盟(CAP)-一个由国防部和退伍军人事务部资助的跨学科和多机构、与军事相关的创伤后应激障碍研究联盟-生成和应用CDE，可用于结合来自不同研究的数据，以改进研究结果的方法和统计能力。我们提供了CAP CDE的描述和基本原理，以及关于管理的详细信息，主要有两个目标：(1)鼓励与军事相关的创伤后应激障碍研究人员在未来的研究中使用这些措施；(2)促进比较、复制和数据汇总。材料和方法：CAP基于以下标准编制了授权的(核心)和可选的CDE：(1)构建对军事相关创伤后应激障碍的适用性；(2)优先(使用)先前的相关研究；(3)已发表的强有力的心理测量学证据；(4)无成本(公共领域)；以及(5)简洁性，以限制参与者的负担。我们从参加CAP研究的大约400名参与者的初始队列中，为强制措施提供了描述性统计和内部一致性可靠性。结果：CAP中的强制CDE具有很好的内部一致性信度。结论：虽然这些CDE的增量效度还需要进一步的研究，但初步分析表明，每一种强制测量都具有很好的内部一致性信度。设计与军事相关的创伤后应激障碍研究的调查人员应该考虑使用这些经过现场测试的CDE来促进未来的数据汇总。欢迎基于经验证据或实际关注的反馈来改善这些CDE。
Introduction: Driven by the need to share data, sufficiently power studies, and allow for cross-study comparisons of medical and psychiatric diseases, the President's National Research Action Plan issued in 2013 called for the use of state-of-the-art common data elements (CDEs) for research studies. CDEs are variables measured across independent studies that facilitate methodologically sound data aggregation and study replication. Researchers in the field of military-related post-traumatic stress disorder (PTSD) have suggested applicable CDEs; however, to date, these recommendations have been conceptual and not field-tested. The Consortium to Alleviate PTSD (CAP) -an interdisciplinary and multi-institutional, military-related PTSD research consortium funded by the Departments of Defense and Veterans Affairs -generated and applied CDEs that can be used to combine data from disparate studies to improve the methodological and statistical capabilities of study findings. We provide a description and rationale for the CAP CDEs and details about administration with two main goals: (1) to encourage military-related PTSD researchers to use these measures in future studies and (2) to facilitate comparison, replication, and data aggregation. Materials and Methods: The CAP compiled mandated (core) and optional CDEs based on the following criteria: (1) construct applicability to military-related PTSD; (2) precedence (use) in prior, related research; (3) published and strong psychometric evidence; (4) no cost (public domain); and (5) brevity, to limit participant burden. We provided descriptive statistics and internal consistency reliabilities for mandated measures from an initial cohort of around 400 participants enrolled in CAP studies. Results: Mandated CDEs in the CAP were found to have very good internal consistency reliability. Conclusion: Although further research is needed to determine the incremental validity of these CDEs, preliminary analyses indicated that each mandated measure has very good internal consistency reliability. Investigators designing militaryrelated PTSD research should consider using these field-tested CDEs to facilitate future data aggregation. Feedback based on empirical evidence or practical concerns to improve these CDEs is welcome.