Behavioral effects of (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, (DOI) in the elevated plus-maze test.
Behavioral effects of (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, (DOI) in the elevated plus-maze test.
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(l-)-1-(2,5-二甲氧基-4-碘苯基)-2-氨基丙烷 (DOI) 在高架十字迷宫测试中的行为影响。
DOI：
10.1016/0024-3205(95)02242-9
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发表时间：
1995
期刊：
影响因子：
6.1
通讯作者：
Sanders-Bush,E
中科院分区：
文献类型：
--
作者：
Onaivi,ES;Bishop-Robinson,C;Darmani,NA;Sanders-Bush,E
The serotonin (5-hydroxytryptamine, 5-HT) system has consistently been implicated in the actions of (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and other hallucinogens. Recent evidence suggest that the 5-HT2A/2Creceptor subtypes may be major targets for such drugs in the CNS. DOI-treated hooded rats (0.1–5.0 mg/kg) and DOI treated ICR mice (0.1–2.0 mg/kg), displayed aversions at lower doses and antiaversions at higher doses to the open arms of the plus-maze. Mianserin (0.5 mg/kg) and ketanserin (0.1 mg/kg) blocked the anti-aversive behavior, but only mianserin was effective at reversing the aversions produced by the higher doses of DOI in the ICR mice. DOI produced an intense aversion in the DBA/2 and anti-aversion in the C57/BL6 mice to the open arms of the plus-maze. These opposing actions of DOI in the plus-maze may be exploited in studying the neurobehavioral effects of hallucinogens. Since flumazenil was ineffective at blocking the DOI induced changes, it was concluded that the mechanism of DOI induced anxiolysis or anxiogenesis may not involve an action at the benzodiazepine receptors.
