Collagen-Based Biomaterials for Tissue Engineering Applications
Collagen-Based Biomaterials for Tissue Engineering Applications
复制标题
DOI：
10.3390/ma3031863
复制
发表时间：
2010-03-16
期刊：
影响因子：
3.4
通讯作者：
Berthod F
中科院分区：
文献类型：
--
作者：
Parenteau-Bareil R;Gauvin R;Berthod F
胶原蛋白是人体内分布最广泛的一类蛋白质。胶原基生物材料在组织工程领域的应用在过去几十年中得到了广泛的发展。研究了多种交联方法，并探索了与其他生物聚合物的不同组合，以改善组织功能。胶原蛋白具有生物可降解、生物相容、易于获得和高度通用的主要优点。然而，由于胶原蛋白是一种蛋白质，因此在不改变其结构的情况下仍然难以灭菌。本文综述了胶原基生物材料在组织工程中的各种应用，旨在提供一种从实验室工作台到患者床边的再生医学功能材料。
Collagen is the most widely distributed class of proteins in the human body. The use of collagen-based biomaterials in the field of tissue engineering applications has been intensively growing over the past decades. Multiple cross-linking methods were investigated and different combinations with other biopolymers were explored in order to improve tissue function. Collagen possesses a major advantage in being biodegradable, biocompatible, easily available and highly versatile. However, since collagen is a protein, it remains difficult to sterilize without alterations to its structure. This review presents a comprehensive overview of the various applications of collagen-based biomaterials developed for tissue engineering, aimed at providing a functional material for use in regenerative medicine from the laboratory bench to the patient bedside.