The epidemiology of fetal alcohol syndrome and partial FAS in a South African community
The epidemiology of fetal alcohol syndrome and partial FAS in a South African community
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DOI：
10.1016/j.drugalcdep.2006.11.007
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发表时间：
2007-05-11
影响因子：
4.2
通讯作者：
Viljoen, Denis L.
中科院分区：
文献类型：
--
作者：
May, Philip A.;Gossage, J. Phillip;Viljoen, Denis L.
目的：胎儿酒精综合征（FAS）和部分胎儿酒精综合征（PFAS）的患病率和特点，确定在第三小学队列在南非（SA）的社区。方法：一个积极的情况下确定，两层筛选方法，和修订后的医学研究所诊断标准之间的818名一年级学生。FAS和PEAS儿童的特征与随机选择的对照组进行对比。数据收集和分析的儿童在研究中关于：（1）身体的生长和发育，包括畸形，（2）智力和行为特征，（3）他们的母亲的社会，行为和物理characteristics.Results：FAS和PFAS在这方面的比率继续作为最高的报告在任何整体社区，是远远高于其他地方的利率。在这一组中，每1000人中有68.0-89.2人。患有FAS和PEAS儿童的母亲在周末严重的间歇性饮酒占所有饮酒量的96%。母亲饮酒的各种措施与儿童在非语言智力（-0.26），语言智力（-0.28），问题行为（0.31）和整体畸形评分（0.59）方面的负面结果显着相关。农村儿童FAS和PFAS患病率明显高于农村儿童（OR = 3.79）。结论：该社区儿童FAS和PFAS患病率再次升高，且呈上升趋势。鉴于人口相似性，我们怀疑南非西开普省的其他社区也有很高的发病率。需要制定预防方案。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
Objectives: The prevalence and characteristics of fetal alcohol syndrome (FAS) and partial fetal alcohol syndrome (PFAS) were determined in a third primary school cohort in a community in South Africa (SA).Methods: An active case ascertainment, two-tier screening methodology, and the revised Institute of Medicine diagnostic criteria were employed among 818 first grade pupils. Characteristics of children with FAS and PEAS are contrasted with a randomly selected control group. Data were collected and analyzed for children in the study regarding: (1) physical growth and development, including dysmorphology, (2) intelligence and behavioral characteristics, and (3) their mother's social, behavioral, and physical characteristics.Results: The rate of FAS and PFAS in this area continues as the highest reported in any overall community and is much higher than rates elsewhere. In this cohort it is 68.0-89.2 per 1000. Severe episodic drinking on weekends among mothers of children with FAS and PEAS accounts for 96% of all alcohol consumed. Various measures of maternal drinking are significantly correlated with negative outcomes of children in the areas of non-verbal intelligence (-0.26), verbal intelligence (-0.28), problem behavior (0.31), and overall dysmorphology score (0.59). Significantly more FAS and PFAS exists among children of rural residents (OR = 3.79).Conclusions: A high rate of FAS and PFAS was again documented in this community, and it has increased. Given population similarities, we suspect that other communities in the Western Cape Province of South Africa also have high rates. Programs for prevention are needed. (c) 2006 Elsevier Ireland Ltd. All rights reserved.