Obesity from cradle to grave
Obesity from cradle to grave
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DOI：
10.1038/sj.ijo.0802278
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发表时间：
2003-06-01
影响因子：
4.9
通讯作者：
Barker, D
中科院分区：
文献类型：
--
作者：
Eriksson, J;Forsén, T;Barker, D
背景技术背景：肥胖是一种从幼年到成年的跟踪性疾病。目的：研究成年期肥胖与儿童期生长发育和生活条件的关系。设计：出生队列研究。参与者：共4515人1934年至1944年间出生于赫尔辛基大学中心医院的2135名男性和2380名女性，测量：肥胖发生率基于一生最大体重指数（BMI），BMI定义为BMI大于或等于30 kg/m2。主要的解释性测量是在出生时的大小，儿童期的生长，在儿童期和成人lifes.Results的社会经济地位：肥胖的累积发病率为33.8%，男性和女性的32.4%。发病率随着出生时体型的增大而升高。从出生开始，那些后来变得肥胖的人的平均体重和BMI超过了平均值，并且在6个月到12岁的所有年龄段都保持在统计学显著水平。儿童时期的BMI比出生时的身体尺寸更能预测成人肥胖。怀孕期间母亲BMI较高与儿童期生长更快和成年后肥胖风险增加有关。较高的社会经济地位和较好的教育程度与较低的肥胖患病率相关。母乳喂养的持续时间和后来的obesity.CONCLUSIONS：这些结果强调了早期生活因素在成人肥胖症发病机制中的重要性。
BACKGROUND: Obesity is known to track from early life into adult life.OBJECTIVE: To examine the relation of obesity in adult life to growth and living conditions during childhood.DESIGN: Birth cohort study.PARTICIPANTS: A total of 4515 people (2135 men and 2380 women) who were born at Helsinki University Central Hospital between 1934 and 1944, who attended child welfare clinics and were still resident in Finland in the year 2000.MEASUREMENTS: Incidence of obesity based upon lifetime maximum body mass index (BMI) ascertained from a postal questionnaire and defined as a BMIgreater than or equal to30 kg/m(2). The main explanatory measurements were size at birth, childhood growth, and socioeconomic status in childhood and in adult life.RESULTS: The cumulative incidence of obesity was 33.8% in men and 32.4% in women. The incidence rose with increasing body size at birth. From birth the mean weight and BMI of people who later became obese exceeded the average and remained above average at a statistically significant level at all ages from 6 months to 12y. Childhood BMI was a stronger predictor of adult obesity than body size at birth. A higher maternal BMI in pregnancy was associated with a more rapid childhood growth and an increased risk of becoming obese in adult life. Higher socioeconomic status and better educational attainment were associated with a lower prevalence of obesity. There was no association between the duration of breastfeeding and later obesity.CONCLUSIONS: These results emphasize the importance of early life factors in the pathogenesis of adult obesity.