The "His and Hers" of the Renin-Angiotensin System
The "His and Hers" of the Renin-Angiotensin System
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DOI：
10.1007/s11906-012-0319-y
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发表时间：
2013-02-01
影响因子：
5.6
通讯作者：
Denton, Kate M.
中科院分区：
文献类型：
--
作者：
Hilliard, Lucinda M.;Sampson, Amanda K.;Denton, Kate M.
性别差异存在于动脉血压和肾功能的调节由肾素-血管紧张素系统（RAS）。这可能部分源于RAS的升压臂和降压臂中的差异平衡。在男性中，ACE/AngII/AT（1）R途径增强，而在女性中，平衡向ACE 2/Ang（1-7）/MasR和AT（2）R途径转移。有证据清楚地表明，与年龄匹配的男性相比，绝经前女性免受肾脏和心血管疾病的影响，这种性别之间RAS的差异平衡可能是原因之一。随着年龄的增长，女性的心血管保护功能丧失，这可能与绝经后雌激素的丧失有关，但其他性激素的可能作用需要进一步研究。在老年女性中恢复这些RAS抑制通路，或在男性中上调这些通路，是值得追求的治疗目标。
Sex differences exist in the regulation of arterial pressure and renal function by the renin-angiotensin system (RAS). This may in part stem from a differential balance in the pressor and depressor arms of the RAS. In males, the ACE/AngII/AT(1)R pathways are enhanced, whereas, in females, the balance is shifted towards the ACE2/Ang(1-7)/MasR and AT(2)R pathways. Evidence clearly demonstrates that premenopausal women, as compared to aged-matched men, are protected from renal and cardiovascular disease, and this differential balance of the RAS between the sexes likely contributes. With aging, this cardiovascular protection in women is lost and this may be related to loss of estrogen postmenopause but the possible contribution of other sex hormones needs to be further examined. Restoration of these RAS depressor pathways in older women, or up-regulation of these in males, represents a therapeutic target that is worth pursuing.