A Statistical Review of Controlled Trials of Imipramine and Placebo in the Treatment of Depressive Illnesses
A Statistical Review of Controlled Trials of Imipramine and Placebo in the Treatment of Depressive Illnesses
复制标题
丙咪嗪和安慰剂治疗抑郁症对照试验的统计回顾
DOI：
10.1192/bjp.127.6.599
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发表时间：
1975
影响因子：
10.5
通讯作者：
P. Clay
中科院分区：
文献类型：
--
作者：
S. C. Rogers;P. Clay
摘要本文介绍了一种通过提取2 × 2表格形式的基本数据并通过Fisher双尾精确检验分析这些数据来回顾一系列临床试验的方法，并以已发表的丙咪嗪-安慰剂试验为例进行了说明。结果表明，这种药物对尚未住院的内源性抑郁症患者的益处是无可争议的，并且在这种情况下进行进一步的药物安慰剂试验是不合理的。丙咪嗪治疗神经症抑郁症的三项试验中有两项结果显示出显着的改善。这种药物在未分化的抑郁症患者群体中的明显失败的可能解释进行了讨论。
Summary A method of reviewing a series of clinical trials by extracting the basic data in the form of 2 × 2 tables and analysing these by Fisher's two-tailed Exact Test is described, and illustrated by published imipramine-placebo trials. The results suggest that the benefit of this drug in patients with endogenous depression who have not become institutionalized is indisputable, and that further drug-placebo trials in this condition are not justified. Two of the three trials of imipramine in neurotic depression gave results showing significant improvement. Possible explanations of the apparent failure of this drug in groups of patients with undifferentiated depression are discussed.