The needle length of bacterial injectisomes is determined by a molecular ruler
The needle length of bacterial injectisomes is determined by a molecular ruler
复制标题
DOI：
10.1126/science.1091422
复制
发表时间：
2003-12-05
期刊：
影响因子：
56.9
通讯作者：
Cornelis, GR
中科院分区：
文献类型：
--
作者：
Journet, L;Agrain, C;Cornelis, GR
尺寸测定代表了多组分生物结构的基本要求。一些致病细菌拥有来自鞭毛的武器。与鞭毛一样，这种被称为注射体的III型分泌器具有跨膜基体，但外部组件是针状结构，而不是钩子和a。哀叹。在这里，我们提供的证据表明，该针的长度是由充当分子标尺的蛋白质 YscP 的大小决定的。
Size determination represents a fundamental requirement for multicomponent biological structures. Some pathogenic bacteria possess a weapon derived from the flagellum. Like the flagellum, this type-III secretion apparatus, called the injectisome, has a transmembrane basal body, but the external component is a needle-like structure instead of a hook and a. lament. Here, we provide evidence that the length of this needle is determined by the size of a protein, YscP, acting as a molecular ruler.