Electrical arrhythmias in the human stomach.
Electrical arrhythmias in the human stomach.
复制标题
人胃中的电心律失常。
作者：
C. Stoddard;R. Smallwood;H. Duthie
本文用单极粘膜电极记录了136例胃窦部迷走神经切断术前后的肌电活动，用双极塞氏电极记录了136例胆囊切除术后的胃窦部肌电活动，并观察了胃窦部心律失常的发生率。62例迷走神经切断术后患者中有5例出现持续时间较长的心律失常，胆囊切除术后10例患者中有1例出现持续时间较长的心律失常，但术前患者中没有出现心律失常。它们的特征是频率增加的慢波，可变周期，振幅和波形，并与慢波抑制期。心律失常患者均无任何胃动力障碍症状。在某些患者中，使用胰岛素、促胰液素、胆囊收缩素-胰酶素、胰高血糖素和五肽胃泌素也可诱发窦性心律失常。胃窦心律失常的出现可能是由于交感神经活动相对于副交感神经活动增加。观察到的最大慢波频率为每分钟8.3个周期，并且很可能体内人胃窦平滑肌具有最大频率，高于该最大频率时，胃窦平滑肌不能被驱动。
Myoelectrical activity was recorded from the human antrum on 136 occasions using a monopolar mucosal electrode in preoperative and post-vagotomy patients, and bipolar serosal electrodes in post-cholecystectomy patients, and the incidence of antral arrhythmias observed. Arrhythmias of long duration were observed in five out of 62 patients after vagotomy and one out of 10 patients after cholecystectomy, but not in preoperative patients. They were characterised by slow waves with increased frequency, variable period, amplitude, and wave shape and were associated with periods of slow wave inhibition. None of the patients with an arrhythmia had any symptoms of disordered gastric motility. Antral arrhythmias could also be induced in some patients by the administration of insulin, secretin, cholecystokinin-pancreozymin, glucagon, and pentagastrin. The appearance of antral arrhythmias is probably due to a relative increase of sympathetic over parasympathetic activity. The maximal slow wave frequency observed was 8.3 cycles per minute and it is probable that in vivo human antral smooth muscle has a maximum frequency above which it cannot be driven.