Propitious Therapeutic Modulators to Prevent Blood-Spinal Cord Barrier Disruption in Spinal Cord Injury
Propitious Therapeutic Modulators to Prevent Blood-Spinal Cord Barrier Disruption in Spinal Cord Injury
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DOI：
10.1007/s12035-016-9910-6
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发表时间：
2017-07-01
影响因子：
5.1
通讯作者：
Han, Inbo
中科院分区：
文献类型：
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作者：
Kumar, Hemant;Ropper, Alexander E.;Han, Inbo
血脊髓屏障（BSCB）是一种特殊的保护屏障，调节血管和脊髓实质之间的分子运动。与血脑屏障（BBB）类似，BSCB在维持中枢神经系统（CNS）的稳态和内部环境稳定方面起着至关重要的作用。脊髓损伤（SCI）后，BSCB破坏导致炎性细胞入侵，如中性粒细胞和巨噬细胞，导致永久性神经功能障碍。在这篇综述中，我们集中在SCI后介导BSCB破坏或BSCB修复的主要蛋白质。本文共分三个部分。第1款. SCI和BSCB描述了SCI病理生理学中涉及的关键事件及其与BSCB完整性/破坏的相关性。第2款.参与SCI中BSCB破坏的主要蛋白质集中于基质金属蛋白酶（MMPs）、肿瘤坏死因子α（TNF-α）、血红素加氧酶-1（HO-1）、血管生成素（Angs）、缓激肽、一氧化氮（NO）和内皮素（ET）在BSCB破坏和修复中的作用。第3款.治疗方法讨论了迄今为止通过调节几种蛋白质来预防SCI动物模型中BSCB破坏的主要治疗化合物。
The blood-spinal cord barrier (BSCB) is a specialized protective barrier that regulates the movement of molecules between blood vessels and the spinal cord parenchyma. Analogous to the blood-brain barrier (BBB), the BSCB plays a crucial role in maintaining the homeostasis and internal environmental stability of the central nervous system (CNS). After spinal cord injury (SCI), BSCB disruption leads to inflammatory cell invasion such as neutrophils and macrophages, contributing to permanent neurological disability. In this review, we focus on the major proteins mediating the BSCB disruption or BSCB repair after SCI. This review is composed of three parts. Section 1. SCI and the BSCB of the review describes critical events involved in the pathophysiology of SCI and their correlation with BSCB integrity/disruption. Section 2. Major proteins involved in BSCB disruption in SCI focuses on the actions of matrix metalloproteinases (MMPs), tumor necrosis factor alpha (TNF-alpha), heme oxygenase-1 (HO-1), angiopoietins (Angs), bradykinin, nitric oxide (NO), and endothelins (ETs) in BSCB disruption and repair. Section 3. Therapeutic approaches discusses the major therapeutic compounds utilized to date for the prevention of BSCB disruption in animal model of SCI through modulation of several proteins.