Differing influences of virus burden and immune activation on disease severity in secondary dengue-3 virus infections
Differing influences of virus burden and immune activation on disease severity in secondary dengue-3 virus infections
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DOI：
10.1086/340365
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发表时间：
2002-05-01
影响因子：
6.4
通讯作者：
Rothman, AL
中科院分区：
文献类型：
--
作者：
Libraty, DH;Endy, TP;Rothman, AL
登革出血热（DHF）是登革热病毒感染后最严重的疾病形式，其特征是血浆渗漏、血小板减少和肝脏炎症。在参与一项前瞻性医院研究的54名继发性登革3型病毒感染儿童中，检查了病毒负荷、免疫激活和DHF发展之间的相互关系。DHF与疾病早期较高的平均血浆病毒血症和较早的血浆干扰素-γ峰值水平相关。最大血浆病毒血症水平与血浆渗漏和血小板减少的程度相关。白细胞介素（IL）-10和可溶性肿瘤坏死因子受体-II的最大血浆水平与血小板减少的程度相关，独立于病毒血症水平。肝转氨酶升高与血浆可溶性IL-2受体水平相关，而与病毒血症水平无关。病毒负荷和宿主免疫应答的定量差异以及1型细胞因子应答的时间对继发性登革-3病毒感染期间疾病表现的严重程度具有不同的影响。
Dengue hemorrhagic fever (DHF), the most severe form of illness following infection with a dengue virus, is characterized by plasma leakage, thrombocytopenia, and hepatic inflammation. The interrelationships among virus burden, immune activation, and development of DHF were examined in 54 children with secondary dengue-3 virus infections participating in a prospective, hospital-based study. DHF was associated with higher mean plasma viremia early in illness and earlier peak plasma interferon-gamma levels. Maximum plasma viremia levels correlated with the degree of plasma leakage and thrombocytopenia. Maximum plasma levels of interleukin (IL)-10 and soluble tumor necrosis factor receptor-II correlated with the degree of thrombocytopenia, independently of viremia levels. Hepatic transaminase elevation correlated with plasma soluble IL-2 receptor levels and not with viremia levels. Quantitative differences in virus burden and host immune responses, and the timing of type 1 cytokine responses, have differing influences on the severity of disease manifestations during secondary dengue-3 virus infections.