Coxiella burnetii - Pathogenic Agent of Q (Query) Fever
Coxiella burnetii - Pathogenic Agent of Q (Query) Fever
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DOI：
10.1159/000357107
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发表时间：
2014-01-01
影响因子：
2.2
通讯作者：
Willkommen, Hannelore
中科院分区：
文献类型：
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作者：
Guertler, Lutz;Bauerfeind, Ursula;Willkommen, Hannelore
C.burnetii 是 Coxiellaceae 细菌家族的成员，并在不同物种的细胞中进行细胞内复制。系统发育相关的细菌包括军团菌科、弗朗西斯菌科、假单胞菌科和其他伽马变形菌。柯克斯体是小型革兰氏阴性、多形性、球状细菌，大小为 0.2–1.0 µm。它们以 3 种不同的形式出现：具有高度传染性的小细胞（小细胞变体，SCV），也在细胞培养中发育的大细胞（大细胞变体，LCV），以及具有传染性且对环境条件非常稳定的孢子样颗粒（SLP）。根据宿主系统的不同，柯克斯体在生长过程中会经历相位变化[12]。在哺乳动物细胞中，细菌以 LCV 形式生长，并形成孢子样颗粒和 2 种不同的抗原形式，称为 I 期和 II 期。
C. burnetii is a member of the family of the Coxiellaceae bacteria and replicates intracellularly in cells of different species. Phylogenetically related bacteria include Legionellaceae, Francisellaceae, Pseudomonaceae, and other Gammaproteobacteria. Coxiella are small Gram-negative, pleomorphic, coccoid bacteria with a size of 0.2–1.0 µm. They occur in 3 different forms: small cells (small cell variant, SCV) which are highly infectious, large cells (large cell variant, LCV) which develop also in cell culture, as well as spore-like particles (SLP) which are infectious and very robust to environmental conditions. Dependent on the host system, Coxiella undergoes a phase variation during growth [12]. In mammalian cells, bacteria grow as LCV, and form spore-like particles and 2 different antigenic forms described as Phase I and II.