Muscle differentiation: more complexity to the network of myogenic regulators
Muscle differentiation: more complexity to the network of myogenic regulators
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DOI：
10.1016/s0959-437x(98)80008-7
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发表时间：
1998-10-01
影响因子：
4
通讯作者：
Winter, B
中科院分区：
文献类型：
--
作者：
Arnold, HH;Winter, B
最近的遗传和生化方法加深了我们对脊椎动物肌生成控制机制的理解。特别是，小鼠中靶向基因破坏的系统组合揭示了建立骨骼肌细胞谱系的调控网络中转录因子 MyoD 家族成员的独特且重叠的功能。此外，Pax3 已被确定为肌生成的关键调节因子，其似乎在 MyoD 的遗传上游发挥作用。此外，还发现了新的基因以正向或负向方式调节肌生成和肌源性碱性螺旋-环-螺旋（bHLH）蛋白的活性。这些相互作用和协同作用的分子机制正在被阐明，尤其是肌源性 bHLH 因子和 MEF2 转录因子之间的相互作用和协同作用的分子机制。
Recent genetic and biochemical approaches have advanced our understanding of control mechanisms underlying myogenesis in vertebrate organisms. In particular, systematic combinations of targeted gene disruptions in mice have revealed unique and overlapping functions of members of the MyoD family of transcription factors within the regulatory network that establishes skeletal muscle cell lineages. Moreover, Pax3 has been identified as a key regulator of myogenesis which seems to act genetically upstream of MyoD. In addition, novel genes have been discovered that modulate myogenesis and the activity of myogenic basic helix-loop-helix (bHLH) proteins in positive or negative ways. The molecular mechanisms of these interactions and cooperativity are being elucidated, most notably between the myogenic bHLH factors and MEF2 transcription factors.