In situ assembly of magnetic nanocrystals/graphene oxide nanosheets on tumor cells enables efficient cancer therapy
In situ assembly of magnetic nanocrystals/graphene oxide nanosheets on tumor cells enables efficient cancer therapy
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磁性纳米晶体/氧化石墨烯纳米片在肿瘤细胞上的原位组装可实现有效的癌症治疗
DOI：
10.1007/s12274-020-2759-z
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发表时间：
2020
期刊：
影响因子：
9.9
通讯作者：
Yu Shuhong
中科院分区：
文献类型：
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作者：
Liu Mingyang;Lu Yang;Yu Qilin;Yu Shuhong
由于其刺激响应性和动力学特性，磁驱动组装积木形成有序结构一直是一个令人惊奇的研究课题。虽然在理想的物理和化学条件下已经开发了大量的磁性组装体，但在复杂的生物系统中实现磁性组装仍然是一个挑战。本文报道了一种由超顺磁性氧化石墨烯（γ-Fe_2O_3@GO）、肿瘤靶向蛋白转铁蛋白（TF）和靶向多肽（MitP）组成的生物大分子修饰的磁性纳米片。L-Fe_2 O_3@GO-MitP-TF纳米片（0.5-1 μm）可在肿瘤细胞表面原位组装，并具有肿瘤细胞特异性，抑制肿瘤细胞对营养物质的摄取。更重要的是，纳米结构可以有效地限制肿瘤细胞，防止肿瘤细胞在体外和体内的侵袭和转移。此外，2D组装体可以显着破坏线粒体并诱导细胞凋亡，从而在近红外（NIR）照射下显着根除肿瘤。这项研究揭示了新的纳米系统的发展，有效的癌症治疗和其他生物医学应用。
Owing to the stimulus-responsive and dynamic properties, magnetism-driven assembly of building blocks to form ordered structures is always a marvelous topic. While abundant magnetic assemblies have been developed in ideal physical and chemical conditions, it remains a challenge to realize magnetic assembly in complicated biological systems. Herein, we report a kind of biomacromolecule-modified magnetic nanosheets, which are mainly composed of superparamagnetic graphene oxide (γ-Fe_2O_3@GO), the tumor-targeting protein transferrin (TF), and the mitochondrion-targeting peptide (MitP). Such large-size nanosheets (0.5–1 μm), noted as L-Fe_2O_3@GO-MitP-TF, can successfully in situ assemble on the surface of tumor cells in a size-dependent and tumor cell-specific way, leading to severe inhibition of nutrient uptake for the tumor cells. More significantly, the nanostructures could efficiently confine the tumor cells, preventing both invasion and metastasis of tumor cells both in vitro and in vivo. Moreover, the 2D assemblies could remarkably disrupt the mitochondria and induce apoptosis, remarkably eradicating tumors under near-infrared (NIR) irradiation. This study sheds light on the development of new nano-systems for efficient cancer therapy and other biomedical applications.