Influenza virus vaccination in kidney transplant recipients: serum antibody response to different immunosuppressive drugs
Influenza virus vaccination in kidney transplant recipients: serum antibody response to different immunosuppressive drugs
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DOI：
10.1111/j.1399-0012.2009.01095.x
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发表时间：
2010-01-01
影响因子：
2.1
通讯作者：
Machado, Clarisse M.
中科院分区：
文献类型：
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作者：
Salles, Mauro J. C.;Sens, Yvoty A. S.;Machado, Clarisse M.
简介：本研究前瞻性评估了接受硫唑嘌呤或霉酚酸酯（MMF）的肾移植受者对灭活流感疫苗的免疫应答。方法：69例患者接受一剂灭活三价流感疫苗。结果：H1N1和H3 N2毒株的HI抗体几何平均滴度分别从2.57和2.44增加到13.45（p = 0.001）和7.20（p < 0.001）。H1N1和H3 N2疫苗接种前和接种后的保护率从8.7%提高到49.3%（p < 0.001）;和36.3%（p < 0.001），血清转化率分别为36%和25.3%。对B型流感无应答。与使用硫唑嘌呤相比，使用霉酚酸酯降低了H1N1和H3 N2的保护率以及H1N1毒株的血清转化率，并且移植时间小于87个月的受试者的抗体应答也较差。接种流感疫苗后，肾移植患者的肾功能无明显变化。结论：接种流感疫苗后，肾移植患者产生针对流感病毒的抗体。uenza A病毒株，但不用于in。乌恩扎湾B使用霉酚酸酯和较短的移植时间降低了对疫苗的免疫反应。
Introduction: This study prospectively accessed the immune response to the inactivated influenza vaccine in renal transplant recipients receiving either azathioprine or mycophenolate mofetil (MMF). Side effects were investigated.Methods: Sixty-nine patients received one dose of inactivated trivalent influenza vaccine. Antihemagglutinin (HI) antibody response against each strain was measured before and one to six months after vaccination.Results: Geometric mean HI antibody titers for H1N1 and H3N2 strains increased from 2.57 and 2.44 to 13.45 (p = 0.001) and 7.20 (p < 0.001), respectively. Pre- and post-vaccination protection rates for H1N1 and H3N2 increased from 8.7% to 49.3% (p < 0.001); and 36.3% (p < 0.001) and seroconversion rates were 36% and 25.3%, respectively. There was no response to influenza B. The use of MMF reduced the H1N1 and H3N2 protection rates and the seroconversion rate for the H1N1 strain when compared with the use of azathioprine, and subjects transplanted less than 87 months also had inferior antibody response. Adverse events were mild and there were no change on renal function post-vaccination.Conclusion: Renal transplant patients vaccinated against influenza responded with antibody production for in. uenza A virus strains, but not for in. uenza B. Use of MMF and shorter time from transplantation decreased the immune response to the vaccine.