MECHANICAL-PROPERTIES OF TRABECULAR BONE FROM THE PROXIMAL FEMUR - A QUANTITATIVE CT STUDY
MECHANICAL-PROPERTIES OF TRABECULAR BONE FROM THE PROXIMAL FEMUR - A QUANTITATIVE CT STUDY
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DOI：
10.1097/00004728-199001000-00020
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发表时间：
1990-01-01
影响因子：
1.3
通讯作者：
HAYES, WC
中科院分区：
文献类型：
--
作者：
LOTZ, JC;GERHART, TN;HAYES, WC
我们研究了49个新鲜人股骨近端圆柱形标本的松质骨压缩强度和弹性模量与直接测量的表观密度和无创测量的CT等效矿物质密度之间的关系。抗压强度表现出高度的正相关性与这两个密度，是成比例的表观密度提高到1.8的权力（R2 = 0.93）和等效矿物密度的1.5的权力（R2 = 0.89）。类似地，压缩模量与两种密度测量值都表现出高度相关性，与表观密度的1.4次方（R2 = 0.91）和CT等效矿物密度的1.2次方（R2 = 0.90）成比例。尽管观察到结构和骨髓脂肪的变化会影响骨小梁的特性，但本文提供的数据表明，使用单能量定量CT可以准确地确定表观密度、抗压强度和弹性模量。我们期望这些非侵入性数据的使用将导致对髋部骨折风险中归因于骨强度的部分的改进估计。
We have investigated the relationships between trabecular bone compressive strength and elastic modulus and the directly measured apparent density and noninvasively measured CT equivalent mineral density for 49 cylindrical specimens harvested from fresh human proximal femora. Compressive strength demonstrated a high positive correlation with both densities, being proportional to the apparent density raised to the 1.8 power (R2 = 0.93) and equivalent mineral density to the 1.5 power (R2 = 0.89). Similarly, the compressive modulus demonstrated a high correlation with both density measures, being proportional to the apparent density raised to the 1.4 power (R2 = 0.91) and CT equivalent mineral density to the 1.2 power (R2 = 0.90). Though variations in architecture and bone marrow fat were observed to influence trabecular properties, the data presented here demonstrate that apparent density, compressive strength, and elastic modulus can be determined accurately using single energy quantitative CT. We expect that the use of these noninvasive data will result in improved estimates of that component of hip fracture risk that is attributable to bone strength.