Behavioral teratogenic effect of methylmercury and d-amphetamine: meta-analysis and power analysis of data from the Collaborative Behavioral Teratology Study of National Center for Toxicological Research.
Behavioral teratogenic effect of methylmercury and d-amphetamine: meta-analysis and power analysis of data from the Collaborative Behavioral Teratology Study of National Center for Toxicological Research.
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甲基汞和 d-苯丙胺的行为致畸作用：国家毒理学研究中心合作行为致畸研究数据的荟萃分析和功效分析。
DOI：
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
T. Tachibana
中科院分区：
文献类型：
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作者：
T. Tachibana
对协作行为畸胎学研究（CBTS）的数据进行了分析。通过荟萃分析，根据置信区间估计群体效应大小。清楚地观察到甲基汞的治疗效果，并且还观察到剂量反应效应。另一方面，d-苯丙胺研究中没有观察到明显的治疗效果。听觉惊吓习惯化的影响非常大，尽管仅限于甲基汞研究中的高剂量组。总体而言，观察到的物理地标的影响比行为测量的影响要大一些。除了活动测量外，没有明确的证据表明性别相关的差异。观察到了 CBTS 报告中未提及的奇怪治疗效果：甲基汞治疗加速了开眼日和切牙萌出日。功效分析结果表明，获得这些化合物的统计显着效果非常困难，这表明即使已发表的论文报告了这些化合物的显着效果，但可能有许多未发表的实验获得了不显着的效果。如果使用这些化合物作为阳性对照，则需要非常大的样本量。在 CBTS 所采用的测试中，没有观察到跨化合物或剂量水平可重复的高度敏感测试。
The data of the Collaborative Behavioral Teratology Study (CBTS) were analyzed. Population-effect sizes were estimated, in terms of confidence intervals, by meta-analysis. A treatment effect of methylmercury was clearly observed and a dose-response effect was also observed. On the other hand, no clear treatment effect was observed in the d-amphetamine study. The effect of auditory startle habituation was very large, although it was limited to the high-dose group in the methylmercury study. The effects observed for physical landmarks were, as a whole, somewhat larger than those for behavioral measures. There is no clear evidence for sex-related differences except for activity measures. A curious treatment effect that was not referred to in the CBTS report was observed: eye-opening day and incisor-eruption day were hastened by the treatment of methylmercury. Power analysis results showed that obtaining a statistically significant effect for these compounds is very difficult, suggesting that even though published papers reported the significant effect of these compounds there might have been many unpublished experiments that obtained nonsignificant effects. If one uses these compounds as positive controls, a very large sample size will be needed. No highly sensitive test that is reproducible across compounds or dose-levels was observed among tests employed in the CBTS.
跨研究检验假设的方法：畸胎学家和毒理学家的应用。
DOI：
10.1002/tera.1420340115
发表时间：
1986
期刊：
Teratology
影响因子：
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作者：
Barron,S;Jaccard,J;Riley,EP
通讯作者：
Riley,EP