Dual effects of sodium aescinate on vascular tension in rat thoracic aorta
Dual effects of sodium aescinate on vascular tension in rat thoracic aorta
复制标题
七叶皂苷钠对大鼠胸主动脉血管张力的双重作用
DOI：
10.1016/j.mvr.2009.11.002
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发表时间：
2010-01-01
影响因子：
3.1
通讯作者：
Hu, Shen-Jiang
中科院分区：
文献类型：
--
作者：
Li, Xia;Chen, Guo-Ping;Hu, Shen-Jiang
目的：将七叶皂苷钠（SA）作为血管活性药物应用于临床。本研究旨在探讨SA对大鼠离体胸主动脉的影响及其可能的机制。方法：记录器官浴对药物反应的等长张力。结果：SA的作用服从全有或全无的反应。相对低剂量（>= 50 μ g/ml）的SA对大鼠主动脉有不依赖内皮的收缩作用(P
Objective: Sodium aescinate (SA) is used as a vasoactive drug in clinical treatment. This study was designed to investigate the effects of SA on rat isolated thoracic aorta and the possible mechanisms.Methods: Isometric tension was recorded in response to drugs in organ bath.Results: The effects of SA obeyed an all-or-nothing response. SA in relatively low dose (>= 50 mu g/ml) had an endothelium-independent contractile effect in rat aorta (P