Circulating stem cell-like epithelial cell adhesion molecule-positive tumor cells indicate poor prognosis of hepatocellular carcinoma after curative resection
Circulating stem cell-like epithelial cell adhesion molecule-positive tumor cells indicate poor prognosis of hepatocellular carcinoma after curative resection
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DOI：
10.1002/hep.26151
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发表时间：
2013-04-01
期刊：
影响因子：
13.5
通讯作者：
Fan, Jia
中科院分区：
文献类型：
--
作者：
Sun, Yun-Fan;Xu, Yang;Fan, Jia
上皮细胞粘附分子阳性（EpCAM+）肝细胞癌（HCC）细胞可能构成致瘤细胞系和HCC标本中的肿瘤起始亚群。在本研究中，EpCAM+循环肿瘤细胞（CTCs）进行了前瞻性的肝癌患者接受根治性切除，并进一步研究其预后意义和干细胞样特征。在切除前和切除后1个月检测了123例HCC患者的血液样本。CTC存在于66.67%的患者中，并且在7.5mL血液中测量的细胞计数（CTC 7.5）范围在1和34之间。51例患者术前CTC 7.5为2，这些患者的肿瘤复发早于CTC 7.5为2的患者。
Epithelial cell adhesion moleculepositive (EpCAM+) hepatocellular carcinoma (HCC) cells may constitute a tumor-initiating subpopulation in tumorigenic cell lines and HCC specimens. In the present study, EpCAM+ circulating tumor cells (CTCs) were identified prospectively in HCC patients undergoing curative resection, and the prognostic significance and their stem celllike characteristics were investigated further. Blood samples from 123 HCC patients were tested prior to resection and 1 month thereafter. CTCs were present in 66.67% of patients, and the cell count measured in 7.5 mL of blood (CTC7.5) ranged between 1 and 34. Fifty-one patients had CTC7.5 of 2 preoperatively, and these patients developed tumor recurrence earlier than those with CTC7.5 of