Modelling the STDP symmetry-to-asymmetry transition in the presence of GABAergic inhibition
Modelling the STDP symmetry-to-asymmetry transition in the presence of GABAergic inhibition
复制标题
在 GABA 能抑制存在的情况下对 STDP 对称到不对称转变进行建模
DOI：
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
B. Graham
中科院分区：
文献类型：
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作者：
Vassilis Cutsuridis;S. Cobb;B. Graham
实验研究表明，海马CA 1区锥体神经元近端中间层（SR）树突的发放时间依赖性可塑性（STDP）曲线存在由不对称到不对称的转变，这可能是GABA能抑制的结果。最近的一个计算模型预测，对称性到不对称性的转变强烈依赖于GABA抑制的频率和电导值，并且对称性STDP曲线的最大长时程增强（LTP）值和两个不同的长时程抑制（LTD）尾部分别集中在+10 ms，+40 ms和~10 ms。在本文中，我们继续通过计算机模拟进一步研究γ频率抑制及其电导值对SR树突中STDP轮廓的对称性到不对称性转变的影响，并预测当前后兴奋性刺激和GABA能抑制的起始之间存在时间偏移时，这种转变甚至更稳健。最大的LTP值和两个明显的LTD尾与GABA电导的增加成反比。
Experimental studies have shown a symmetry-to-asymmetry transition of the spike-timing dependent plasticity (STDP) curve exists in the proximal stratum ntdiatum (SR) dendrite of the hippocampal CAl pyramidal neuron, which is probably due to the presence of GABAergic inhibition. A recent computational model predicted that symmetry-to-asymmetry transition is strongly dependent on the frequency and conductance value of GABA inhibition and that the largest long term potentiation (LTP) value and the two distinct long-term depression (LTD) tails of the symmetrical STDP curve are centred at +10 ms, +40 ms and ~10 ms, respectively. In the present paper, we continue to investigate even further via computer simulations the effects of gamma frequency inhibition and its conductance value to the symmetry-to-asymmetry transition of the STDP profile in the SR dendrite and predict that the transition is even more robust when there is a t,cmporal offset betwern the onsets of the pre-post excitatory stimulation and the GABAergic inhibition. The largest LTP value and the two distinct LTD tails are inversely proportional to the increase of GABA conductance.
影响因子：
2.5
作者：
J. Rubin;R. C. Gerkin;Guoqiang Bi;Carson C. Chow
通讯作者：
J. Rubin;R. C. Gerkin;Guoqiang Bi;Carson C. Chow