Incidence of cancer in children aged 0-14 years in Taiwan, 1996-2010
Incidence of cancer in children aged 0-14 years in Taiwan, 1996-2010
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DOI：
10.1016/j.canep.2014.11.010
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发表时间：
2015-02-01
影响因子：
2.6
通讯作者：
Lai, Mei-Shu
中科院分区：
文献类型：
--
作者：
Liu, Yen-Lin;Lo, Wei-Cheng;Lai, Mei-Shu
研究发现，亚洲儿童患癌症的风险较低。本研究旨在探讨自1995年3月全民健保实施以来，台湾儿童癌症的发生率与趋势。数据来自台湾癌症登记处，这是一个建立于1979年的基于人群的数据库。根据国际儿童癌症分类第三版（ICCC-3）对1996年至2010年0-14岁诊断的病例进行分析和分类。共纳入8032例儿童癌症病例，显微镜验证率为93.9%。按2000年世界标准人口调整的整体年龄标准化发病率为125.0例/百万人，男女比例为1.3。前五位癌症类型（ICCC-3亚组; ASR/百万）为急性淋巴细胞白血病（Ia，30.3）、急性髓性白血病（Ib; 9.4）、非霍奇金淋巴瘤（IIb，c，e，9.0）、颅外生殖细胞肿瘤（Xb，c; 8.3）和神经母细胞瘤（IVa; 7.8）。男性和女性的中位诊断年龄均为6岁。在研究期间，儿童癌症的ASR以每年1.2%的速度增加（95%置信区间，0.6-1.7%）。与西方国家相比，中国、日本和台湾的儿童癌症发病率较低;然而，台湾的儿童生殖细胞肿瘤和肝脏肿瘤发病率较高。总的来说，这项以人口为基础的研究显示，台湾儿童癌症的发病率持续上升。生殖细胞肿瘤的高发病率值得进一步研究。(C)2014爱思唯尔有限公司版权所有。
Studies have found lower risk of childhood cancer among Asian children. We aim to characterize the recent incidence and incidence-trend of childhood cancer in Taiwan after the National Health Insurance program was launched in March 1995. Data were extracted from the Taiwan Cancer Registry, a population-based database established in 1979. Cases diagnosed at age 0-14 from 1996 to 2010 were analyzed and categorized according to the International Classification of Childhood Cancer, Third Edition (ICCC-3). In total, 8032 childhood cancer cases were included, with a microscopic verification rate of 93.9%. The overall age-standardized rate (ASR) of incidence adjusted to the 2000 World Standard Population is 125.0 cases/million, with a male-to-female ratio of 1.3. The top five cancer types (ICCC-3 subgroup[s]; ASR per million) are acute lymphoblastic leukemia (Ia, 30.3), acute myeloid leukemia (Ib; 9.4), non-Hodgkin lymphoma (IIb, c,e, 9.0), extracranial germ cell tumor (Xb,c; 8.3), and neuroblastoma (IVa; 7.8). The median age of diagnosis was 6 years for both genders. During the study period, the ASR of childhood cancer has been increasing at a rate of 1.2% per year (95% confidence interval, 0.6-1.7%). In contrast to Western countries, China, Japan, and Taiwan have lower incidence of childhood cancer; however, Taiwan's incidence rates of childhood germ cell tumors and hepatic tumors are higher. In conclusion, this population-based study reveals that the incidence rate of childhood cancer in Taiwan is rising consistently. The high incidence of germ cell tumors warrants further investigation. (C) 2014 Elsevier Ltd. All rights reserved.