Longitudinal study using voxel-based relaxometry: Association between cartilage T1ρ and T2 and patient reported outcome changes in hip osteoarthritis.
Longitudinal study using voxel-based relaxometry: Association between cartilage T1ρ and T2 and patient reported outcome changes in hip osteoarthritis.
复制标题
使用基于体素的松弛测量法的纵向研究：软骨 T1α 和 T2 与患者报告的髋骨关节炎结果变化之间的关联。
DOI：
10.1002/jmri.25458
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Majumdar,Sharmila
中科院分区：
文献类型：
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作者：
Pedoia,Valentina;Gallo,MatthewC;Souza,RichardB;Majumdar,Sharmila
PurposeTo研究髋关节软骨T1ρ和T2弛豫时间的局部分布及其与患者报告的结果测量（PROMs）的变化之间的关系，使用全自动，局部和无偏的方法在受试者与非髋关节骨关节炎（OA.Materials and MethodsThe 3特斯拉MRI研究的髋关节获得37名健康对照和16名受试者与放射学髋关节OA。成像方案包括三维（3D）SPGR序列和组合的3D T1ρ和T2序列。比较了传统的基于感兴趣区域（ROI）的方法和全自动基于体素的松弛测量（VBR）方法之间的定量软骨分析。此外，VBR被用来评估局部T1ρ和T2的差异与受试者和没有OA，并评估T1ρ和T2和18个月的变化PROMs之间的关联。结果两种方法的结果是一致的髋臼（R = 0.79;变异系数[CV] = 2.9%）和股骨软骨（R = 0.90; CV = 2.6%）。VBR显示OA患者T1ρ和T2升高的局部模式，特别是在髋臼后上软骨（T1ρ：P= 0.02; T2：P= 0.038）。总体而言，基线时较高的T1ρ和T2值，特别是髋臼前上软骨（T1ρ：Rho =-0.42;P= 0.002; T2：Rho =-0.44;P= 0.002），与18个月随访时PROMS恶化相关。VBR显示出检测有和无骨关节炎受试者T1ρ和T2值局部变化的能力，基于体素的相关性表明基线T1ρ和T2值与PROM变化之间存在区域依赖性。MAGN. RESON.影像2017;45：1523-1533
PurposeTo study the local distribution of hip cartilage T1ρand T2relaxation times and their association with changes in patient reported outcome measures (PROMs) using a fully automatic, local, and unbiased method in subjects with and without hip osteoarthritis (OA).Materials and MethodsThe 3 Tesla MRI studies of the hip were obtained for 37 healthy controls and 16 subjects with radiographic hip OA. The imaging protocol included a three‐dimensional (3D) SPGR sequence and a combined 3D T1ρand T2sequence. Quantitative cartilage analysis was compared between a traditional region of interest (ROI)‐based method and a fully automatic voxel‐based relaxometry (VBR) method. Additionally, VBR was used to assess local T1ρand T2differences between subjects with and without OA, and to evaluate the association between T1ρand T2and 18‐month changes PROMs.ResultsResults for the two methods were consistent in the acetabular (R = 0.79; coefficients of variation [CV] = 2.9%) and femoral cartilage (R = 0.90; CV = 2.6%). VBR revealed local patterns of T1ρand T2elevation in OA subjects, particularly in the posterosuperior acetabular cartilage (T1ρ:P= 0.02; T2:P= 0.038). Overall, higher T1ρand T2values at baseline, particularly in the anterosuperior acetabular cartilage (T1ρ: Rho = ‐0.42;P= 0.002; T2: Rho = ‐0.44;P= 0.002), were associated with worsening PROMS at 18‐month follow‐up.ConclusionVBR is an accurate and robust method for quantitative MRI analysis in hip cartilage. VBR showed the capability to detect local variations in T1ρand T2values in subjects with and without osteoarthritis, and voxel based correlations demonstrated a regional dependence between baseline T1ρand T2values and changes in PROMs.Level of Evidence: 1J. MAGN. RESON. IMAGING 2017;45:1523–1533