EFFERENT PATHWAY OF THE AMYGDALA INVOLVED IN CONDITIONED FEAR AS MEASURED WITH THE FEAR-POTENTIATED STARTLE PARADIGM
EFFERENT PATHWAY OF THE AMYGDALA INVOLVED IN CONDITIONED FEAR AS MEASURED WITH THE FEAR-POTENTIATED STARTLE PARADIGM
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DOI：
10.1037/0735-7044.105.6.826
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发表时间：
1991-12-01
影响因子：
1.9
通讯作者：
DAVIS, M
中科院分区：
文献类型：
--
作者：
HITCHCOCK, JM;DAVIS, M
大鼠的恐惧增强惊吓是一种条件性恐惧的量度，它被杏仁核中央核的损伤所阻断。 在另一项研究中，罗森、希区柯克、萨南内斯、米塞伦迪诺和戴维斯（1991）证明了从中央核到脑干惊吓反射回路的直接解剖投射。 在本研究中，恐惧增强惊吓被阻断的病变，中断这一途径在3个不同的水平或交叉病变，中断的途径在其源的一侧，并在更尾部的水平上的另一侧。 虽然突触中继尚未完全排除，数据表明，从中央杏仁核的惊吓电路介导的恐惧增强惊吓的表达的直接投射。 这些发现与文献一致，表明从中央核到各种脑干结构的传出投射参与了几种条件性恐惧反应的表达。
Fear-potentiated startle in the rat is a measure of conditioned fear that is blocked by lesions of the central nucleus of the amygdala. In a companion study, Rosen, Hitchcock, Sananes, Miserendino, and Davis (1991) demonstrated a direct anatomical projection from the central nucleus to the brainstem startle reflex circuit. In the present study, fear-potentiated startle was blocked by lesions that interrupted this pathway at 3 different levels or by a crossed lesion that interrupted the pathway at its source on one side and at a more caudal level on the other side. Although synaptic relays have not been ruled out entirely, the data suggest that the direct projection from the central nucleus of the amygdala to the startle circuit mediates the expression of fear-potentiated startle. These findings are consistent with the literature indicating that efferent projections from the central nucleus to various brainstem structures are involved in the expression of several conditioned fear responses.