Cell Therapy Strategies vs. Paracrine Effect in Huntington's Disease.
Cell Therapy Strategies vs. Paracrine Effect in Huntington's Disease.
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DOI：
10.14802/jmd.14001
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发表时间：
2014-04
影响因子：
3.9
通讯作者：
Kim M
中科院分区：
文献类型：
--
作者：
Im W;Kim M
亨廷顿病（HD）是一种遗传性神经退行性疾病。HD最常见的症状是异常的不自主扭动运动，称为舞蹈病。抗精神病药和丁苯那嗪用于缓解HD的体征和症状。已经研究了干细胞用于神经退行性疾病以开发细胞治疗策略。最近的证据表明，干细胞疗法的有益效果实际上是由分泌分子以及细胞替代介导的。虽然干细胞研究表明，细胞移植在体内模型中提供了病变周围的细胞改善，但在干细胞临床应用之前，还需要进一步的工作来阐明一些问题。这些问题包括确切的作用机制、给药方法、毒性和安全性。本文以HD为重点，综述了细胞治疗策略和干细胞的旁分泌作用。
Huntington’s disease (HD) is a genetic neurodegenerative disorder. The most common symptom of HD is abnormal involuntary writhing movements, called chorea. Antipsychotics and tetrabenazine are used to alleviate the signs and symptoms of HD. Stem cells have been investigated for use in neurodegenerative disorders to develop cell therapy strategies. Recent evidence indicates that the beneficial effects of stem cell therapies are actually mediated by secretory molecules, as well as cell replacement. Although stem cell studies show that cell transplantation provides cellular improvement around lesions in in vivo models, further work is required to elucidate some issues before the clinical application of stem cells. These issues include the precise mechanism of action, delivery method, toxicity and safety. With a focus on HD, this review summarizes cell therapy strategies and the paracrine effect of stem cells.