Components of depression in HIV-1 infection: Their differential relationship to neurocognitive performance
Components of depression in HIV-1 infection: Their differential relationship to neurocognitive performance
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DOI：
10.1080/13803390590935444
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发表时间：
2006-04-01
影响因子：
2.2
通讯作者：
Moore, L
中科院分区：
文献类型：
--
作者：
Castellon, SA;Hardy, DJ;Moore, L
抑郁症和神经认知功能损害在人类免疫缺陷病毒（HIV）感染者中很常见。到目前为止，大多数研究都没有找到一个一致的关系之间的情绪和认知艾滋病毒血清阳性（HIV+）的个人，这表明这些结构是相互独立的。然而，抑郁症是一个多维度的综合征，其测量通常使用包含认知，情感，躯体和动机成分的多因素工具。抑郁症的各种症状或维度与HIV-1感染的神经心理学表现的相关程度通常没有探讨，这是目前研究的主要目的。样本247艾滋病毒阳性的人完成了全面的神经认知电池和贝克抑郁量表（BDI）的一部分，在一个主要的社区医院的标准临床评价。为了研究BDI的维度，进行了主成分分析，提出了一个三因素的解决方案，包括代表自我责备（SR），情绪动机障碍（MM），和躯体障碍（SOM）的因素。每一个这三个因素和神经认知性能之间的关系进行了检查，使用回归和方差分析技术。这些分析表明，MM因素，比SR或SOM因素，与神经认知性能的几个方面，包括言语记忆，执行功能，和运动速度。这些发现表明，抑郁症评定量表上的某些项目可能比其他项目更能表明中枢神经系统（CNS）的参与。情绪和动机障碍与神经认知损害之间的关联可能表明，每一种都是疾病特定机制的后遗症。
Both depression and neurocognitive compromise are commonly observed among persons infected with the Human Immunodeficiency Virus (HIV). To date, the majority of studies have failed to find a consistent relationship between mood and cognition among HIV-seropositive (HIV+) individuals, suggesting that these constructs are independent of one another. However, depression is a multi-dimensional syndrome and its measurement often utilizes multi-factorial instruments containing cognitive, affective, somatic, and motivational components. The degree to which various symptoms or dimensions of depression might be related to neuropsychological performance in HIV-1 infection is not typically explored and was a main objective of the current study. A sample of 247 HIV+ persons completed both a comprehensive neurocognitive battery and the Beck Depression Inventory (BDI) as part of a standard clinical evaluation at a major community hospital. To examine the dimensionality of the BDI, a principal components analysis was conducted which suggested a three-factor solution comprised of factors representing Self-Reproach (SR), Mood-Motivation Disturbance ( MM), and Somatic Disturbance (SOM). The relationship between each of these three factors and neurocognitive performance was examined using both regression and analysis of variance techniques. These analyses showed the MM factor, more so than either the SR or SOM factors, to be associated with several aspects of neurocognitive performance, including verbal memory, executive functioning, and motor speed. These findings suggest that certain items on depression rating scales may be more indicative of central nervous system (CNS) involvement than others. The association between disturbance in mood and motivation and neurocognitive compromise may suggest that each are sequelae of disease specific mechanisms.