Changes in ventilatory responses to hypercapnia and hypoxia after intermittent hypoxia in humans
Changes in ventilatory responses to hypercapnia and hypoxia after intermittent hypoxia in humans
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DOI：
10.1016/j.resp.2004.11.007
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发表时间：
2005-03-01
影响因子：
2.3
通讯作者：
Miyamura, M
中科院分区：
文献类型：
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作者：
Katayama, K;Sato, K;Miyamura, M
本研究的目的是阐明间歇性缺氧和缺氧暴露停止后高碳酸血症和缺氧通气反应（HCVR 和 HVR）的变化。 29名男性被分配到四组之一，即实验1中的低氧组（EX1-H，n = 7）或对照（EX1-C，n = 7）组，以及实验2中的低氧组（EX2-H，n = 8）或对照（EX2-C，n = 7）组。在每个实验中，利用低氧帐篷系统进行间歇性低氧，帐篷内的氧气水平为维持在 12.3 +/- 0.2%。在实验1中，EX I-H组每天在低氧帐篷中呆3小时，持续1周。在间歇性缺氧 1 周之前和之后测定 HCVR 和 HVR，并在停止缺氧暴露后 1 周和 2 周再次测定。在实验2中，EX2-H组的受试者在间歇性缺氧中进行为期两周的每天3小时的训练。在间歇性缺氧前后进行HCVR和HVR测试，并在停止缺氧2周后再次重复。 EX1-H组在间歇缺氧1周后HCVR斜率没有表现出明显增加，而EX2-H组在间歇缺氧2周后HCVR明显增加。间歇性缺氧 1 或 2 周后 HCVR 截距没有变化。间歇性缺氧 1 周和 2 周后，HVR 斜率显着增加。缺氧停止2周后，增加的HCVR和HVR恢复到缺氧前水平。这些结果表明，持续 2 周、每天 3 小时的间歇性缺氧导致中枢高碳酸血症通气化疗敏感性增加，但并不伴随中枢化学感受器的重置，并且增加的高碳酸血症和缺氧化疗敏感性在缺氧停止后 2 周内恢复。 (c) 2004 Elsevier B.V. 保留所有权利。
The purpose of this study was to clarify the changes in hypercapnic and hypoxic ventilatory responses (HCVR and HVR) after intermittent hypoxia and following the cessation of hypoxic exposure. Twenty-nine males were assigned to one of four groups, i.e., a hypoxic (EX1-H, n = 7) or a control (EX1-C, n = 7) group in Experiment 1, and a hypoxic (EX2-H, n = 8) or a control (EX2-C, n = 7) group in Experiment 2. In each experiment, the hypoxic tent system was utilized for intermittent hypoxia, and the oxygen levels in the tent were maintained at 12.3 +/- 0.2%. In Experiment 1, the EX I-H group spent 3 h/day in the hypoxic tent for 1 week. HCVR and HVR were determined before and after 1 week of intermittent hypoxia, and again I and 2 week after the cessation of hypoxic exposure. In Experiment 2, the subjects in the EX2-H group performed 3 h/day for 2 weeks in intermittent hypoxia. HCVR and HVR tests were carried out before and after intermittent hypoxia, and were repeated again after 2 weeks of the cessation of hypoxic exposure. The slope of the HCVR in the EX1-H group did not show a significant increase after I week of intermittent hypoxia, while HCVR in the EX2-H group increased significantly after 2 weeks of intermittent hypoxia. The HCVR intercept was unchanged following 1 or 2 weeks of intermittent hypoxia. There was a significant increase in the slope of the HVR after 1 and 2 weeks of intermittent hypoxia. The increased HCVR and HVR returned to pre-hypoxic levels after 2 weeks of the cessation of hypoxia. These results suggest that 3 h/day for 2 weeks of intermittent hypoxia leads to an increase in central hypercapnic ventilatory chemosensitivity, which is not accompanied by a re-setting of the central chemoreceptors, and that the increased hypercapnic and hypoxic chemosensitivities are restored within 2 weeks after the cessation of hypoxia. (c) 2004 Elsevier B.V. All rights reserved.