Inflammation-induced lethargy is mediated by suppression of orexin neuron activity.
Inflammation-induced lethargy is mediated by suppression of orexin neuron activity.
复制标题
炎症诱导的嗜睡是通过抑制Orexin神经元活性介导的。
DOI：
10.1523/jneurosci.2311-11.2011
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发表时间：
2011-08-03
期刊：
影响因子：
--
通讯作者：
Marks DL
中科院分区：
文献类型：
--
作者：
Grossberg AJ;Zhu X;Leinninger GM;Levasseur PR;Braun TP;Myers MG Jr;Marks DL
为了应对疾病，动物破坏了正常的体内平衡，并将其能量利用转移到对抗感染上。这种反应的一个重要和未探索的特征是在负能量平衡的情况下抑制身体活动和觅食行为。下丘脑中的炎症信号介导了对疾病的发热和厌食反应，但运动活动（LMA）被抑制的机制尚未被描述。外侧下丘脑（LHA）食欲素（Ox）神经元将能量状态与LMA联系起来，Ox信号传导的缺陷导致活动减退和摄食不足。在目前的工作中，我们研究了内毒素诱导的炎症对牛神经元生物学和大鼠LMA的影响。我们的研究结果表明，减少Ox信号在介导炎症诱导的嗜睡中起着至关重要的作用。这项工作定义了一个特定的炎症敏感的，觉醒相关的Ox神经元群体，并确定了炎症信号传导到Ox神经元的近端神经靶点，同时消除了其他几个。
In response to illness, animals subvert normal homeostasis and divert their energy utilization to fight infection. An important and unexplored feature of this response is the suppression of physical activity and foraging behavior in the setting of negative energy balance. Inflammatory signaling in the hypothalamus mediates the febrile and anorectic responses to disease, but the mechanism by which locomotor activity (LMA) is suppressed has not been described. Lateral hypothalamic (LHA) orexin (Ox) neurons link energy status with LMA, and deficiencies in Ox signaling lead to hypoactivity and hypophagia. In the present work, we examine the effect of endotoxin-induced inflammation on Ox neuron biology and LMA in rats. Our results demonstrate a vital role for diminished Ox signaling in mediating inflammation-induced lethargy. This work defines a specific population of inflammation-sensitive, arousal-associated Ox neurons and identifies a proximal neural target for inflammatory signaling to Ox neurons, while eliminating several others.