Synthetic biodegradable polymers as drug delivery systems for bone morphogenetic proteins.
Synthetic biodegradable polymers as drug delivery systems for bone morphogenetic proteins.
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DOI：
10.1016/j.addr.2004.12.016
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发表时间：
2005-05
影响因子：
16.1
通讯作者：
Naoto Saito;Narumichi Murakami;Jun Takahashi;H. Horiuchi;Hiroyoshi Ota;Hiroyuki Kato;T. Okada;K. Nozaki;Kunio Takaoka
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文献类型：
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作者：
Naoto Saito;Narumichi Murakami;Jun Takahashi;H. Horiuchi;Hiroyoshi Ota;Hiroyuki Kato;T. Okada;K. Nozaki;Kunio Takaoka
骨形态发生蛋白（BMP）在体内诱导骨形成，在骨折和骨缺损修复中的临床应用前景广阔。然而，需要开发用于临床使用的适当的系统来递送BMP。我们合成了一种新的合成生物降解聚合物，聚-d，l-乳酸-对-二氧环己酮-聚乙二醇嵌段共聚物（PLA-DX-PEG），作为生物相容性，生物降解聚合物的重组人（rh）BMP-2的交付系统。在动物实验中，PLA-DX-PEG/rhBMP-2复合材料可有效地形成新骨，并修复大面积骨缺损。此外，这种新的聚合物可用作rhBMP-2的注射递送系统。rhBMP-2/PLA-DX-PEG复合材料还可以与其他材料如羟基磷灰石或钛结合。这种新的合成聚合物可能用于rhBMP-2在各种临床情况下，包括骨修复，导致骨科治疗的巨大变化。
Bone morphogenetic proteins (BMP) induce bone formation in vivo, and clinical application in repair of bone fractures and defects is expected. However, appropriate systems to deliver BMP for clinical use need to be developed. We synthesized a new synthetic biodegradable polymer, poly-d,l-lactic acid-para-dioxanone-polyethylene glycol block copolymer (PLA-DX-PEG), to serve as a biocompatible, biodegradable polymer for recombinant human (rh) BMP-2 delivery systems. In animal experiments, new bone was efficiently formed and a large bone defect was repaired using PLA-DX-PEG/rhBMP-2 composites. In addition, this new polymer could be used as an injectable delivery system for rhBMP-2. The rhBMP-2/PLA-DX-PEG composites also could be combined with other materials such as hydroxyapatite or titanium. This new synthetic polymer might be used for rhBMP-2 delivery in various clinical situations involving repair of bone, leading to great changes in orthopedic treatment.