Biotransformation and bioactivation reactions - 2015 literature highlights.
Biotransformation and bioactivation reactions - 2015 literature highlights.
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DOI：
10.1080/03602532.2016.1195404
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发表时间：
2016-05-01
影响因子：
5.9
通讯作者：
Cyrus Khojasteh, S
中科院分区：
文献类型：
--
作者：
Baillie, Thomas A;Dalvie, Deepak;Cyrus Khojasteh, S
自 1972 年以来，Drug Metabolism Reviews 已被公认为药理学、制药和毒理学领域研究人员了解学术界和制药行业药物代谢科学进展的主要资源之一。该期刊拥有杰出的作者和编辑名单，涵盖的主题从细胞色素 P450 酶等相对成熟的领域到各种新兴领域。我们希望通过当前的迷你评论纲要延续这一传统，重点介绍去年发表的新颖的生物转化过程。每篇评论都以文章摘要开始，然后是我们对研究的新颖方面及其生物学意义的评论。本亮点集并不是详尽无遗的，而是为了说明最近的研究，这些研究提供了推动药物代谢领域发展的新见解或方法。缩写 NAPQI N-乙酰基-对苯醌亚胺 ALDH 醛脱氢酶 AO 醛氧化酶 AKR 醛酮还原酶 CES 羧酸酯酶 CSB 胱硫醚β-合酶 CSE 胱硫醚γ-裂解酶 P450 细胞色素 P450 DHPO 2,3-二氢吡啶-4-一 ESI 电喷雾 FMO 黄素单加氧酶GSH 谷胱甘肽 GSSG 谷胱甘肽二硫化物 ICPMS 电感耦合等离子体质谱 i.p.腹腔内 MDR 多重耐药 NNAL 4-(甲基亚硝基氨基)-1-(3-吡啶基)-1-丁醇 NNK 4-(甲基亚硝基氨基)-1-(3-吡啶基)-1-丁酮 oaTOF 正交加速飞行时间 PBK 生理动力学 PCP 五氯酚 SDR 短链脱氢酶/还原酶 SULT 磺基转移酶 TB结核病。
Since 1972, Drug Metabolism Reviews has been recognized as one of the principal resources for researchers in pharmacological, pharmaceutical and toxicological fields to keep abreast of advances in drug metabolism science in academia and the pharmaceutical industry. With a distinguished list of authors and editors, the journal covers topics ranging from relatively mature fields, such as cytochrome P450 enzymes, to a variety of emerging fields. We hope to continue this tradition with the current compendium of mini-reviews that highlight novel biotransformation processes that were published during the past year. Each review begins with a summary of the article followed by our comments on novel aspects of the research and their biological implications. This collection of highlights is not intended to be exhaustive, but rather to be illustrative of recent research that provides new insights or approaches that advance the field of drug metabolism. Abbreviations NAPQI N-acetyl-p-benzoquinoneimine ALDH aldehyde dehydrogenase AO aldehyde oxidase AKR aldo-keto reductase CES carboxylesterase CSB cystathionine beta-synthase CSE cystathionine gamma-lyase P450 cytochrome P450 DHPO 2,3-dihydropyridin-4-one ESI electrospray FMO flavin monooxygenase GSH glutathione GSSG glutathione disulfide ICPMS inductively coupled plasma mass spectrometry i.p. intraperitoneal MDR multidrug-resistant NNAL 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol NNK 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone oaTOF orthogonal acceleration time-of-flight PBK physiologically based kinetic PCP pentachlorophenol SDR short-chain dehydrogenase/reductase SULT sulfotransferase TB tuberculosis.