Combined effects of radiation and trauma.
Combined effects of radiation and trauma.
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DOI：
10.1016/0273-1177(89)90438-9
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发表时间：
1989-01-01
期刊：
影响因子：
--
通讯作者：
Messerschmidt, O
中科院分区：
文献类型：
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作者：
Messerschmidt, O
由全身照射和伤口或烧伤引起的损伤的研究相对较少。可能是因为许多研究人员认为这些损伤只是经过修改的辐射引起的疾病，相同的治疗原则是有效的。例如，其他作者的印象是，辐射烧伤创伤是一种新的疾病，它与单独的辐射综合症或烧伤疾病有很大不同。许多动物实验数据表明，复合损伤的病理学与辐射引起的疾病或热或机械创伤的病理学显着不同。当动物受到全身辐射时，通常不会引起败血症的伤口或烧伤可能成为细菌的入口。血小板减少症是伤口出血的原因。复合损伤中对休克的敏感性显着增加，并且骨折中骨痂的形成显着延迟。辐射综合症初始阶段的伤口和烧伤的愈合并不总是与未受辐射的生物体的愈合不同。然而，几天或几周后，可能会发生非常严重的伤口感染和出血。额外的损伤几乎总是会恶化辐射引起的疾病的发展和预后。复合损伤的推荐治疗方法在许多方面与伤口和烧伤或放射综合征的治疗方法不同。
Injuries, caused by both whole-body irradiation and wounds or burns, have been relatively little studied. Possibly because many investigators think that these injuries are just modified radiation-induced diseases for which the same treatment principles are valid. Other authors had the impression that, for instance, the radiation burn trauma is a new kind of disease which differs significantly from either radiation syndrome alone or from burn disease. There are many experimental data on animals which suggest that the pathology of combined injuries differs significantly from that of radiation-induced disease or of thermal or mechanical traumas. Wounds or burns which, in general, do not cause septicaemia could become entrance ports for bacteria when animals are exposed to whole-body irradiation. Thrombocytopenia is the reason for hemorrhages in wounds. The susceptibility to shock is increased considerably in combined injuries and the formation of callus in the bone fractures is significantly delayed. The healing of wounds and burns in the initial phase of the radiation syndrome does not always differ from healing in the non-irradiated organism. However, a few days or weeks later very serious wound infections and hemorrhages can occur. The additional injuries almost always worsen the development and prognosis of radiation-induced disease. The recommended treatment for combined injuries will differ in many respects from the treatment of wounds and burns or the radiation syndrome.