Time course of organ failure in patients with septic shock treated with hydrocortisone: results of the Corticus study

Time course of organ failure in patients with septic shock treated with hydrocortisone: results of the Corticus study
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DOI:
10.1007/s00134-011-2334-x
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发表时间:
2011-11-01
影响因子:
38.9
通讯作者:
Vincent, J. -L.
Vincent, J. -L.
中科院分区:
医学1区
文献类型:
--
作者:
Moreno, R.;Sprung, C. L.;Vincent, J. -L.

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前言:皮质类固醇已被提出用于降低感染性休克患者的发病率和死亡率。对发病率的影响应该比对死亡率的影响更早和更容易被发现。方法:对感染性休克患者28天的死亡率进行前瞻性、随机、双盲、安慰剂对照研究。
Introduction: Corticosteroids have been proposed to decrease morbidity and mortality in patients with septic shock. An impact on morbidity should be anticipated to be earlier and more easily detected than the impact on mortality. Methods: Prospective, randomized, double-blind, placebo-controlled study of 28-day mortality in patients with septic shock for